Pyrin
A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
Year introduced: 2017 (1997)
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Subheadings:
Tree Number(s): D12.776.220.909, D12.776.934.750
MeSH Unique ID: D000071198
Entry Terms:
- Marenostrin
- MEFV Protein
- Mediterranean Fever Protein
- TRIM20 Protein
See Also: