Suppressor of Cytokine Signaling 3 Protein
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.
Year introduced: 2017
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Subheadings:
Tree Number(s): D12.644.360.024.374.750, D12.776.157.057.249.750, D12.776.476.024.437.750
MeSH Unique ID: D000071223
Entry Terms:
- SOCS3 Protein
- Protein, SOCS3
- Suppressor of Cytokine Signaling Protein 3
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