F-Box-WD Repeat-Containing Protein 7

A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.

Year introduced: 2018

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Tree Number(s): D08.811.464.938.750.750.750, D12.776.157.169.750, D12.776.167.242

MeSH Unique ID: D000073979

Entry Terms:

• F Box WD Repeat Containing Protein 7
• FBXW7 Protein
• F-Box and WD-40 Domain-Containing Protein 7
• F Box and WD 40 Domain Containing Protein 7

Previous Indexing:

• Cell Cycle Proteins (2006-2017)
• F-Box Proteins (2006-2017)
• Ubiquitin-Protein Ligases (2006-2017)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Ligases
Ubiquitin-Protein Ligase Complexes
Ubiquitin-Protein Ligases
SKP Cullin F-Box Protein Ligases
F-Box-WD Repeat-Containing Protein 7

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Carrier Proteins
F-Box Proteins
F-Box-WD Repeat-Containing Protein 7

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Cell Cycle Proteins
F-Box-WD Repeat-Containing Protein 7