Ubiquitin-Protein Ligase Complexes

Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).

Year introduced: 2004

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Tree Number(s): D08.811.464.938

MeSH Unique ID: D043743

Registry Number: EC 2.3.2.23

Entry Terms:

• Complexes, Ubiquitin-Protein Ligase
• Ligase Complexes, Ubiquitin-Protein
• Ubiquitin Protein Ligase Complexes

Previous Indexing:

• Ligases (1983-2003)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Ligases
Ubiquitin-Protein Ligase Complexes
Ubiquitin-Activating Enzymes
Ubiquitin-Conjugating Enzymes
Ubiquitin-Protein Ligases
Anaphase-Promoting Complex-Cyclosome +
Fanconi Anemia Complementation Group L Protein
Inhibitor of Apoptosis Proteins +
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Nedd4 Ubiquitin Protein Ligases
Polycomb Repressive Complex 1
Proto-Oncogene Proteins c-cbl
Proto-Oncogene Proteins c-mdm2
Receptors, Autocrine Motility Factor
SKP Cullin F-Box Protein Ligases +
Tripartite Motif-Containing Protein 28
Tumor Necrosis Factor alpha-Induced Protein 3
Von Hippel-Lindau Tumor Suppressor Protein