Nedd4 Ubiquitin Protein Ligases

E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.

Year introduced: 2018 (1996)

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Tree Number(s): D05.500.199.500, D08.811.464.938.750.257, D12.776.543.990.493.500

MeSH Unique ID: D000075702

Registry Number: EC 2.3.2.26

Entry Terms:

• Nedd4 Proteins
• Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
• Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase

All MeSH Categories
Chemicals and Drugs Category
Macromolecular Substances
Multiprotein Complexes
Endosomal Sorting Complexes Required for Transport
Nedd4 Ubiquitin Protein Ligases

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Ligases
Ubiquitin-Protein Ligase Complexes
Ubiquitin-Protein Ligases
Nedd4 Ubiquitin Protein Ligases

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Membrane Proteins
Vesicular Transport Proteins
Endosomal Sorting Complexes Required for Transport
Nedd4 Ubiquitin Protein Ligases