Tripartite Motif-Containing Protein 28

A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.

Year introduced: 2018

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Tree Number(s): D08.811.464.938.750.782, D12.776.260.703.675, D12.776.930.780.911, D12.776.934.875

MeSH Unique ID: D000076183

Registry Number: EC 2.3.2.27

Entry Terms:

• Tripartite Motif Containing Protein 28
• TRIM28 Protein

Previous Indexing:

• Repressor Proteins (2004-2017)

See Also:

• RING Finger Domains
• PHD Zinc Fingers

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Ligases
Ubiquitin-Protein Ligase Complexes
Ubiquitin-Protein Ligases
Tripartite Motif-Containing Protein 28

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Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
DNA-Binding Proteins
Repressor Proteins
Tripartite Motif-Containing Protein 28

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Transcription Factors
Repressor Proteins
Tripartite Motif-Containing Protein 28

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Tripartite Motif Proteins
Tripartite Motif-Containing Protein 28