Mechanistic Target of Rapamycin Complex 1

An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.

Year introduced: 2018 (2013)

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Tree Number(s): D05.500.337, D08.811.913.696.620.682.700.931.500, D12.776.476.563.931.500

MeSH Unique ID: D000076222

Registry Number: EC 2.7.11.1

Entry Terms:

• TOR Complex 1
• Target of Rapamycin Complex 1
• mTORC1 Complex
• Complex, mTORC1
• TORC1
• mTORC1

All MeSH Categories
Chemicals and Drugs Category
Macromolecular Substances
Multiprotein Complexes
Mechanistic Target of Rapamycin Complex 1
mTOR Associated Protein, LST8 Homolog
Regulatory-Associated Protein of mTOR

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Phosphotransferases
Phosphotransferases (Alcohol Group Acceptor)
Protein Kinases
Protein Serine-Threonine Kinases
TOR Serine-Threonine Kinases
Mechanistic Target of Rapamycin Complex 1
mTOR Associated Protein, LST8 Homolog
Regulatory-Associated Protein of mTOR

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
TOR Serine-Threonine Kinases
Mechanistic Target of Rapamycin Complex 1
mTOR Associated Protein, LST8 Homolog
Regulatory-Associated Protein of mTOR