Anaphylatoxins

Serum peptides derived from certain cleaved COMPLEMENT PROTEINS during COMPLEMENT ACTIVATION. They induce smooth MUSCLE CONTRACTION; mast cell HISTAMINE RELEASE; PLATELET AGGREGATION; and act as mediators of the local inflammatory process. The order of anaphylatoxin activity from the strongest to the weakest is C5a, C3a, C4a, and C5a des-arginine.

Year introduced: 1990(1977)

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Tree Number(s): D12.776.124.486.274.024

MeSH Unique ID: D000706

Entry Terms:

• Anaphylatoxin

Previous Indexing:

• Complement (1968-1976)
• Peptide Fragments (1974-1976)
• Peptides (1966-1976)
• specific complement (1975-1976)

Pharmacologic Action:

• Immunologic Factors

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Blood Proteins
Immunoproteins
Complement System Proteins
Anaphylatoxins
Complement C3a
Complement C4a
Complement C5a
Complement C5a, des-Arginine