Complement C3a
The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.
Year introduced: 2006 (1990)
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Subheadings:
Tree Number(s): D12.776.124.486.274.024.250, D12.776.124.486.274.250.250
MeSH Unique ID: D015926
Registry Number: 80295-42-7
Entry Terms:
- C3a, Complement
- C3a Complement
- Complement, C3a
- Complement 3a
- Complement Component 3a
- Component 3a, Complement
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