Aryl Hydrocarbon Hydroxylases
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
Year introduced: 1975
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Subheadings:
Tree Number(s): D08.244.453.005, D08.811.682.690.708.170.010, D12.776.422.220.453.010
MeSH Unique ID: D001189
Registry Number: EC 1.14.14.1
Entry Terms:
- Hydroxylases, Aryl Hydrocarbon
- Microsomal Monooxygenases
- Monooxygenases, Microsomal
- Xenobiotic Monooxygenases
- Monooxygenases, Xenobiotic
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