Nucleic Acid Hybridization

Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)

Year introduced: 1972(1971)

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Tree Number(s): E05.393.661, G02.111.611

MeSH Unique ID: D009693

Entry Terms:

• Acid Hybridization, Nucleic
• Acid Hybridizations, Nucleic
• Hybridization, Nucleic Acid
• Hybridizations, Nucleic Acid
• Nucleic Acid Hybridizations
• Genomic Hybridization
• Genomic Hybridizations
• Hybridization, Genomic
• Hybridizations, Genomic

Previous Indexing:

• DNA (1966-1970)
• RNA (1966-1970)

See Also:

• Blotting, Southern

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Genetic Techniques
Nucleic Acid Hybridization
Branched DNA Signal Amplification Assay
Comparative Genomic Hybridization
Heteroduplex Analysis
In Situ Hybridization
In Situ Hybridization, Fluorescence +
Primed In Situ Labeling
Oligonucleotide Array Sequence Analysis
Subtractive Hybridization Techniques

All MeSH Categories
Phenomena and Processes Category
Chemical Phenomena
Biochemical Phenomena
Nucleic Acid Hybridization
Base Pairing