Oligonucleotide Probes

Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.

Year introduced: 1989

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Tree Number(s): D13.444.600.601, D27.505.259.750.600.650, D27.720.470.530.600.650

MeSH Unique ID: D015345

Entry Terms:

• Probes, Oligonucleotide
• Oligonucleotide Probe
• Probe, Oligonucleotide
• Oligodeoxyribonucleotide Probes
• Probes, Oligodeoxyribonucleotide
• Oligoribonucleotide Probes
• Probes, Oligoribonucleotide

Previous Indexing:

• Nucleic Acid Hybridization (1972-1988)
• Oligonucleotides (1972-1988)

See Also:

• Nucleic Acid Hybridization
• Oligonucleotide Array Sequence Analysis

All MeSH Categories
Chemicals and Drugs Category
Nucleic Acids, Nucleotides, and Nucleosides
Nucleic Acids
Nucleic Acid Probes
Oligonucleotide Probes

All MeSH Categories
Chemicals and Drugs Category
Chemical Actions and Uses
Pharmacologic Actions
Diagnostic Uses of Chemicals
Molecular Probes
Nucleic Acid Probes
Oligonucleotide Probes

All MeSH Categories
Chemicals and Drugs Category
Chemical Actions and Uses
Specialty Uses of Chemicals
Laboratory Chemicals
Molecular Probes
Nucleic Acid Probes
Oligonucleotide Probes