Ribosomal Protein S6 Kinases

A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.

Year introduced: 2003(1998)

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Tree Number(s): D08.811.913.696.620.682.700.862, D12.776.476.563.862

MeSH Unique ID: D019893

Registry Number: EC 2.7.11.1

Entry Terms:

• Ribosomal Protein S6 Kinase
• S6 Kinase
• S6-H4 Kinase
• S6 H4 Kinase

Previous Indexing:

• Protein Kinases (1985-1992)
• Protein-Serine-Threonine Kinases (1993-1997)

See Also:

• Ribosomal Protein S6
• Coffin-Lowry Syndrome

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Phosphotransferases
Phosphotransferases (Alcohol Group Acceptor)
Protein Kinases
Protein Serine-Threonine Kinases
Ribosomal Protein S6 Kinases
Ribosomal Protein S6 Kinases, 70-kDa
Ribosomal Protein S6 Kinases, 90-kDa

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
Ribosomal Protein S6 Kinases
Ribosomal Protein S6 Kinases, 70-kDa
Ribosomal Protein S6 Kinases, 90-kDa