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Autoimmune Lymphoproliferative Syndrome

Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY.

Year introduced: 2010

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Tree Number(s): C15.604.515.138, C16.320.089, C20.111.288, C20.683.515.124

MeSH Unique ID: D056735

Entry Terms:

  • Autoimmune Lymphoproliferative Syndromes
  • Lymphoproliferative Syndrome, Autoimmune
  • Lymphoproliferative Syndromes, Autoimmune
  • Syndrome, Autoimmune Lymphoproliferative
  • Syndromes, Autoimmune Lymphoproliferative
  • Canale Smith Syndrome
  • Syndrome, Canale Smith
  • Canale-Smith Syndrome
  • Canale-Smith Syndromes
  • Syndrome, Canale-Smith
  • Syndromes, Canale-Smith
  • Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant
  • Autoimmune Lymphoproliferative Syndrome Type 2B
  • Autoimmune Lymphoproliferative Syndrome, Type IIb
  • Caspase-8 Deficiency
  • Caspase-8 Deficiencies
  • Deficiencies, Caspase-8
  • Deficiency, Caspase-8
  • Caspase 8 Deficiency
  • Caspase 8 Deficiencies
  • Deficiencies, Caspase 8
  • Deficiency, Caspase 8
  • Autoimmune Lymphoproliferative Syndrome Type 2B (ALPS2B)
  • Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

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