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Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype selectivity[TRANSFERASE]
View in iCn3D Similar StructuresPubMedProteinsConserved DomainsPubChem Compound
JAK2 JH2 in complex with JAK190[transferase/transferase inhibitor]
JAK2 JH2 in complex with JAK168[transferase/transferase inhibitor]
JAK2 JH2 in complex with JAK179[transferase/transferase inhibitor]
JAK2 JH2 in complex with JAK170[transferase/transferase inhibitor]
JAK2 JH2 in complex with JAK146[transferase/transferase inhibitor]
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model[Transferase/Transferase Inhibitor]
JAK2 JH2 in complex with a diaminopyrimidine[TRANSFERASE/TRANSFERASE INHIBITOR]
JAK2 JH2 in complex with GLPG0634[TRANSFERASE/TRANSFERASE INHIBITOR]
JAK2 JH2 in complex with NVP-BSK805[TRANSFERASE/TRANSFERASE INHIBITOR]
JAK2 JH2 in complex with IKK-2 Inhibitor VI[TRANSFERASE/TRANSFERASE INHIBITOR]
JAK2 JH2 in complex with PRT062607[TRANSFERASE/TRANSFERASE INHIBITOR]
JAK2 JH2 in complex with BI-D1870[TRANSFERASE/TRANSFERASE INHIBITOR]
JAK2 JH2 in complex with AT9283[TRANSFERASE/TRANSFERASE INHIBITOR]
JAK2 JH2 in complex with JNJ-7706621[TRANSFERASE/TRANSFERASE INHIBITOR]
JAK2 JH1 in complex with JNJ-7706621[TRANSFERASE/TRANSFERASE INHIBITOR]
Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin[Transfera...
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