MyD88-deficient macrophage response to lipopolysaccharide and E. coli (dye swap)
Summary:
Analysis of MyD88 null mutant macrophages treated with LPS or live E. coli. MyD88 transduces cell signaling events downstream of Toll-like receptors, a key component of host defense. Results suggest most of the host response to endotoxin or live bacteria is actually regulated independently of MyD88.
GPL1226:
Mouse 13.4K long oligonucleotide array (Operon) 9.10.2002v2
Citation:
Björkbacka H, Fitzgerald KA, Huet F, Li X et al. The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiol Genomics 2004 Nov 17;19(3):319-30. PMID: 15367722
