TATA-binding protein Spt15 mutant response to ethanol and glucose stress
Summary:
Analysis of spt15-300 mutant grown in conditions of ethanol and glucose stress. Mutant generated by global transcription machinery engineering (gTME) and bears 3 mutations in SPT15. Results provide insight into the applicability of gTME to alter cellular eukaryotic phenotypes.
Alper H, Moxley J, Nevoigt E, Fink GR et al. Engineering yeast transcription machinery for improved ethanol tolerance and production. Science 2006 Dec 8;314(5805):1565-8. PMID: 17158319
