Bronchial epithelial cells response to interleukin-22 and interleukin-17
Summary:
Analysis of bronchial epithelial cells treated with interleukin (IL)-22, IL-17, or both. IL-17 receptor mutant lungs are susceptible to Klebsiella pneumonia infections. IL-22 induces antimicrobial peptide expression. Results provide insight into the extent of IL-22 and IL-17's role in host defense.
GPL571:
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Citations:
Aujla SJ, Chan YR, Zheng M, Fei M et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 2008 Mar;14(3):275-81. PMID: 18264110
Adams KM, Abraham V, Spielman D, Kolls JK et al. IL-17A induces Pendrin expression and chloride-bicarbonate exchange in human bronchial epithelial cells. PLoS One 2014;9(8):e103263. PMID: 25141009
