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| Status |
Public on Jan 23, 2008 |
| Title |
Primary Human Bronchial Epithelial Cells (HBEs) Stimulated with IL-22 and IL-17 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Primary HBE cells were stimulated with IL-22 and IL-17, and gene expression was studied using an Affymetrix platform microarray, in order to investigate which genes may be upregulated or downregulated in response to these cytokines. Of particular interest was the host defense genes such as antimicrobial peptides, which have been shown to be upregulated by IL-22 and IL-17 in skin keratinocytes.
Keywords: cytokine effect
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| Overall design |
There were 4 conditions to this study (media, IL-22, IL-17 and IL-22+17) and there were 3 biological replicates of each condition.
Gene expression study using one timepoint of 24 hours after stimulating these primary cells with the above conditions
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| Contributor(s) |
Aujla S, Kolls J |
| Citation(s) |
18264110, 25141009 |
| Submission date |
Jan 23, 2008 |
| Last update date |
Jun 25, 2019 |
| Contact name |
Shean Aujla |
| E-mail(s) |
shean.aujla@chp.edu
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| Phone |
412 692 7338
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| Organization name |
Children's Hospital of Pittsburgh
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| Department |
Division of Pulmonary Medicine, Allergy and Immunology
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| Lab |
Kolls Lab of Lung Immunology and Host Defense
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| Street address |
3460 Fifth Ave
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| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213 |
| Country |
USA |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA108419 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE10240_RAW.tar |
24.9 Mb |
(http)(custom) |
TAR (of CEL, EXP) |
| Processed data included within Sample table |
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