Endogenous Cushing's Syndrome bone biopsies: pre- and post-surgery
Summary:
Analysis of bone biopsies from Cushing’s syndrome (CS) patients, before and mean 3 months after surgical treatment. Excess GC-induced bone loss is a serious complication in patients with endogenous CS. Results provide insight molecular mechanisms by which excess GCs influence bone metabolism.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citations:
Lekva T, Bollerslev J, Kristo C, Olstad OK et al. The glucocorticoid-induced leucine zipper gene (GILZ) expression decreases after successful treatment of patients with endogenous Cushing's syndrome and may play a role in glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab 2010 Jan;95(1):246-55. PMID: 19875485
Lekva T, Ueland T, Bøyum H, Evang JA et al. TXNIP is highly regulated in bone biopsies from patients with endogenous Cushing's syndrome and related to bone turnover. Eur J Endocrinol 2012 Jun;166(6):1039-48. PMID: 22450549
