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| Status |
Public on Apr 08, 2012 |
| Title |
Gene expression analysis of bone biospies from nine patients with endogenous Cushings syndrome before and after treatment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Glucose intolerance and diabetes mellitus are classical parts of endogenous Cushing’s syndrome (CS), and insulin resistance is a feature of cortisol excess. CS patients display characteristics including hyperglycemia, abdominal obesity, reduced high-density lipoprotein cholesterol levels and elevated triglycerides, and arterial hypertension. Hypercortisolism is a well known cause of bone loss, and patients with CS frequently display low bone mass and fragility fractures. Cortisol excess inhibits bone formation, increases bone resorption, impairs calcium absorption from the gut, and affects the secretion of several hormones, cytokines, and growth factors with potential influence on bone metabolism. Bone biopsies from nine CS patients, before and mean 3 months after surgery, were screened for expressional candidate genes using Affymetrix human Gene Plus 2.0 Arrays. Analyses were performed to identify genes in glucocorticoid-induced osteoporosis and genes in glucose metabolism and energy homeostasis.
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| Overall design |
Expression levels were examined in bone biopsy samples from 9 patients with endogenous cushing syndrome, before and mean three months after surgery.
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| Contributor(s) |
Lekva T, Ueland T, Bollerslev J, Olstad OK |
| Citation(s) |
19875485, 22450549 |
| Submission date |
Jun 22, 2011 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Tove Lekva |
| E-mail(s) |
tove.lekva@medisin.uio.no, tove.lekva@ous-hf.no
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| Organization name |
OUS-HF, Rikshospitalet
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| Department |
Section of Specialized Endocrinology and Institute for Internal Medicine
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| Street address |
Sognsvannsveien 20
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| City |
Oslo |
| ZIP/Postal code |
0027 |
| Country |
Norway |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA143923 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30159_RAW.tar |
88.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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