Transcription factor Trps1 GATA-domain deletion effect on embryonic whisker pads
Summary:
Analysis of whisker pads from E12.5 embryos in which the GATA domain of Trps1 has been deleted. Trps1∆gt/∆gt mutants have fewer pelage follicles and lack vibrissae follicles postnatally. Results provide insight into molecular mechanisms underlying vibrissa follicle morphogenesis.
Fantauzzo KA, Christiano AM. Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. Development 2012 Jan;139(1):203-14. PMID: 22115758
