Acute myeloid leukemia with mutated nucleophosmin: bone marrow blasts (test set)
Summary:
Analysis of AML blasts displaying aberrant cytoplasmic localization of nucleophosmin (NPMc+ AML) but negative for AML-associated chromosomal translocations. Results provide insight into the validity of the putative predictors of NPM status identified by the training set.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Alcalay M, Tiacci E, Bergomas R, Bigerna B et al. Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. Blood 2005 Aug 1;106(3):899-902. PMID: 15831697
