FLT3/ITD-SmoM2 acute myeloid leukemia model: sorted bone marrow cells
Summary:
Analysis of KSL and GMP cells isolated from bone marrow of Flt3/ITD-SmoM2 transgenics at around 3 months of age when they developed leukemia. Wild-type and FLT3/ITD littermates of the FLT3/ITD-SmoM2 animals were also examined. Results provide insight into the role of SmoM2 in leukemic progression.
Lim Y, Gondek L, Li L, Wang Q et al. Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Sci Transl Med 2015 Jun 10;7(291):291ra96. PMID: 26062848
