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    ngb neuroglobin [ Danio rerio (zebrafish) ]

    Gene ID: 100000711, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ngbprovided by ZNC
    Official Full Name
    neuroglobinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-011102-1
    See related
    Ensembl:ENSDARG00000053475 AllianceGenome:ZFIN:ZDB-GENE-011102-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Enables nitrite reductase activity and oxygen binding activity. Acts upstream of or within response to hypoxia. Predicted to be located in cytosol and mitochondrial matrix. Is expressed in blood; brain; and eye. Orthologous to human NGB (neuroglobin). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ngb in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (44961948..44968146, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (44848187..44854346, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 22 Neighboring gene transmembrane protein 63C Neighboring gene uncharacterized LOC137488140 Neighboring gene uncharacterized LOC137488141 Neighboring gene FAM161 centrosomal protein B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Improving the cell-membrane-penetrating activity of globins by introducing positive charges on protein surface: A case study of sperm whale myoglobin. Gao SQ, et al. Biochem Biophys Res Commun, 2022 Apr 2. PMID 35151200
    2. Identification of residues critical for the cell-membrane-penetrating activity of zebrafish neuroglobin. Watanabe S, et al. FEBS Lett, 2010 Jun 3. PMID 20417633
    3. Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth. Takahashi N, et al. FEBS Open Bio, 2017 Sep. PMID 28904863, Free PMC Article
    4. Zebrafish reveals different and conserved features of vertebrate neuroglobin gene structure, expression pattern, and ligand binding. Fuchs C, et al. J Biol Chem, 2004 Jun 4. PMID 15140880
    5. Oxygen binding properties of non-mammalian nerve globins. Hundahl C, et al. FEBS J, 2006 Mar. PMID 16519695

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The zebrafish Neuroglobin can catalyze the reduction of nitrite to nitric oxide with a broad range of reaction rate constants.
      Title: Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins.
    2. Data show that the neuroglobin (Ngb) protein was upregulated in the amacrine cells after optic nerve injury.
      Title: A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina.
    3. Chimeric Myoglobin has a cell-membrane-penetrating activity similar to zebrafish Ngb.
      Title: Module M1 of zebrafish neuroglobin acts as a structural and functional protein building block for a cell-membrane-penetrating activity.
    4. both zebrafish and chimeric ZHHH Ngb can penetrate cell membranes in the absence of Chariot
      Title: Zebrafish neuroglobin is a cell-membrane-penetrating globin.
    5. Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin-like function of this protein in facilitated oxygen diffusion
      Title: Zebrafish reveals different and conserved features of vertebrate neuroglobin gene structure, expression pattern, and ligand binding.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC73028

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrite reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on other nitrogenous compounds as donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oxygen transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within oxygen transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuroglobin
    Names
    nitrite reductase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131853.1 → NP_571928.1  neuroglobin

      See identical proteins and their annotated locations for NP_571928.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ315610
      UniProtKB/Swiss-Prot
      B0R176, Q90YJ2
      UniProtKB/TrEMBL
      A0A8M9P002
      Related
      ENSDARP00000069992.4, ENSDART00000075510.6
      Conserved Domains (1) summary
      cl21461
      Location:4 → 150
      Globin_like; Globin-like proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      44961948..44968146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467082.2 → XP_021322757.1  neuroglobin isoform X1

      UniProtKB/Swiss-Prot
      B0R176, Q90YJ2
      UniProtKB/TrEMBL
      A0A8M9P002
      Related
      ENSDARP00000137134.2, ENSDART00000165850.2
      Conserved Domains (1) summary
      cl21461
      Location:4 → 150
      Globin_like; Globin-like proteins

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394998.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      390191..396410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90YJ2.1 GenPept UniProtKB/Swiss-Prot:Q90YJ2

    Gene LinkOut

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