RTL3 retrotransposon Gag like 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RTL3provided by HGNC
Official Full Name: retrotransposon Gag like 3provided by HGNC
Primary source: HGNC:HGNC:22997
See related: Ensembl:ENSG00000179300 MIM:301130; AllianceGenome:HGNC:22997
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Mar3; ZHC5; Mart3; SIRH9; ZCCHC5
Summary: This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. [provided by RefSeq, Nov 2009]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: Xq21.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (78656068..78659328, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (77092886..77096144, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (77911565..77914825, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484135

NoName (e-PCR)
- UniSTS:494432

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retrotransposon Gag-like protein 3

Names: Sushi-Ichi retrotransposon homolog 9; mammalian retrotransposon-derived 3; zinc finger CCHC domain-containing protein 5; zinc finger CCHC-type containing 5; zinc finger, CCHC domain containing 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015973.1 RefSeqGene

Range

5001..8261

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_152694.3 → NP_689907.1 retrotransposon Gag-like protein 3

See identical proteins and their annotated locations for NP_689907.1

Status: REVIEWED

Source sequence(s)

AI091777, AK096184, AL662885

Consensus CDS

CCDS14440.1

UniProtKB/Swiss-Prot

B2RMZ0, Q5JQE9, Q8N8U3

Related

ENSP00000316794.1, ENST00000321110.2

Conserved Domains (3) summary

PHA03160
Location:31 → 161

PHA03160; hypothetical protein; Provisional

pfam00098
Location:443 → 459

zf-CCHC; Zinc knuckle

pfam16297
Location:237 → 316

DUF4939; Domain of unknown function (DUF4939)