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    mpp7a MAGUK p55 scaffold protein 7a [ Danio rerio (zebrafish) ]

    Gene ID: 30166, updated on 27-Mar-2024

    Summary

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    Official Symbol
    mpp7aprovided by ZNC
    Official Full Name
    MAGUK p55 scaffold protein 7aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991209-8
    See related
    Ensembl:ENSDARG00000102470 AllianceGenome:ZFIN:ZDB-GENE-991209-8
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hmp; dlg3; mpp7
    Summary
    Predicted to be located in adherens junction; bicellular tight junction; and membrane. Is expressed in several structures, including hatching gland; nervous system; notochord; otic vesicle; and pectoral fin bud. Orthologous to human MPP7 (MAGUK p55 scaffold protein 7). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See mpp7a in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (23175962..23365873, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (23054743..23244652, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene mohawk homeobox a Neighboring gene outer dynein arm docking complex subunit 2 Neighboring gene WW domain containing adaptor with coiled-coil a Neighboring gene uncharacterized LOC103911922 Neighboring gene BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density. Xiao SM, et al. Hum Mol Genet, 2012 Apr 1. PMID 22171069
    2. U6 promoter-driven siRNA injection has nonspecific effects in zebrafish. Wang L, et al. Biochem Biophys Res Commun, 2010 Jan 15. PMID 20026059
    3. A recessive mutation leading to vertebral ankylosis in zebrafish is associated with amino acid alterations in the homologue of the human membrane-associated guanylate kinase DLG3. König C, et al. Mech Dev, 1999 Aug. PMID 10446262
    4. Drosophila Varicose, a member of a new subgroup of basolateral MAGUKs, is required for septate junctions and tracheal morphogenesis. Wu VM, et al. Development, 2007 Mar. PMID 17267446, Free PMC Article
    5. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Wang L, et al. Development, 2013 Jul. PMID 23698347

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in protein localization to adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAGUK p55 subfamily member 7
    Names
    humpback
    membrane palmitoylated protein 7a
    membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
    membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7)
    protein humpback

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130976.1 → NP_571051.1  MAGUK p55 subfamily member 7

      See identical proteins and their annotated locations for NP_571051.1

      Status: PROVISIONAL

      Source sequence(s)
      AF124435
      UniProtKB/Swiss-Prot
      Q6P0D7
      Related
      ENSDARP00000152963.1, ENSDART00000181711.1
      Conserved Domains (5) summary
      smart00569
      Location:74 → 125
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      smart00072
      Location:377 → 563
      GuKc; Guanylate kinase homologues
      cd00992
      Location:137 → 217
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:369 → 561
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:232 → 292
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      23175962..23365873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306585.3 → XP_009304860.1  MAGUK p55 subfamily member 7 isoform X4

      See identical proteins and their annotated locations for XP_009304860.1

      UniProtKB/Swiss-Prot
      Q6P0D7, Q9PWC1, Q9W7F1
      Related
      ENSDARP00000141751.1, ENSDART00000170376.3
      Conserved Domains (5) summary
      smart00569
      Location:74 → 125
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      smart00072
      Location:377 → 563
      GuKc; Guanylate kinase homologues
      cd00992
      Location:137 → 217
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:369 → 561
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:232 → 292
      SH3; Src Homology 3 domain superfamily

    2. XM_021480018.1 → XP_021335693.1  MAGUK p55 subfamily member 7 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q869
      Conserved Domains (4) summary
      smart00569
      Location:74 → 125
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      smart00072
      Location:377 → 582
      GuKc; Guanylate kinase homologues
      cd00992
      Location:137 → 217
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17036
      Location:232 → 292
      SH3; Src Homology 3 domain superfamily

    3. XM_009306583.3 → XP_009304858.1  MAGUK p55 subfamily member 7 isoform X2

      See identical proteins and their annotated locations for XP_009304858.1

      UniProtKB/TrEMBL
      A0A8M3B7B3
      Conserved Domains (5) summary
      smart00569
      Location:74 → 125
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      smart00072
      Location:403 → 589
      GuKc; Guanylate kinase homologues
      cd00992
      Location:137 → 217
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:395 → 587
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:232 → 292
      SH3; Src Homology 3 domain superfamily

    4. XM_021480017.1 → XP_021335692.1  MAGUK p55 subfamily member 7 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PW28
      Conserved Domains (4) summary
      smart00569
      Location:74 → 125
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      smart00072
      Location:403 → 608
      GuKc; Guanylate kinase homologues
      cd00992
      Location:137 → 217
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17036
      Location:232 → 292
      SH3; Src Homology 3 domain superfamily

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394841.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      220159..222774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P0D7.1 GenPept UniProtKB/Swiss-Prot:Q6P0D7

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