acat2 acetyl-CoA acetyltransferase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: acat2provided by ZNC
Official Full Name: acetyl-CoA acetyltransferase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-990714-22
See related: Ensembl:ENSDARG00000007127 AllianceGenome:ZFIN:ZDB-GENE-990714-22
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb10a06; fb53f08; wu:fb10a06; wu:fb53f08
Summary: Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be active in mitochondrion. Is expressed in liver; nervous system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: chromosome: 20

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (30922595..30931139, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (31019716..31028260, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI497446 (e-PCR)
- UniSTS:206345

fb10a06.x1 (e-PCR)
- UniSTS:202793

fe50c05.x1 (e-PCR)
- UniSTS:196578

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetyl-CoA C-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetyl-CoA acetyltransferase, cytosolic

Names: etID39354.20

NP_571445.2

EC 2.3.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131370.2 → NP_571445.2 acetyl-CoA acetyltransferase, cytosolic

See identical proteins and their annotated locations for NP_571445.2

Status: PROVISIONAL

Source sequence(s)

BC045949

UniProtKB/TrEMBL

Q7ZU18

Related

ENSDARP00000018064.7, ENSDART00000006778.9

Conserved Domains (2) summary

PRK05790
Location:6 → 394

PRK05790; putative acyltransferase; Provisional

cd00751
Location:7 → 394

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...