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    smc2 structural maintenance of chromosomes 2 [ Danio rerio (zebrafish) ]

    Gene ID: 321452, updated on 28-Oct-2024

    Summary

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    Official Symbol
    smc2provided by ZNC
    Official Full Name
    structural maintenance of chromosomes 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-105
    See related
    Ensembl:ENSDARG00000017744 AllianceGenome:ZFIN:ZDB-GENE-030131-105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    SMC2L1; fb92e05; zeh1628; zgc:55326; wu:fb92e05
    Summary
    Predicted to enable chromatin binding activity. Acts upstream of or within DNA damage response and liver development. Predicted to be located in chromatin. Predicted to be part of condensin complex. Predicted to be active in condensed chromosome. Is expressed in several structures, including blood vessel; digestive system; nervous system; optic vesicle; and pectoral fin. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human SMC2 (structural maintenance of chromosomes 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See smc2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (19538299..19561801)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (18845362..18868864)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene clarin 2 Neighboring gene exocyst complex component 1 like Neighboring gene Ecm29 proteasome adaptor and scaffold Neighboring gene F-box protein 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I. Islam KN, et al. Front Cell Dev Biol, 2021. PMID 34434933, Free PMC Article
    2. Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Mönnich M, et al. Gene Expr Patterns, 2009 Dec. PMID 19723591
    3. Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. Ma D, et al. Proc Natl Acad Sci U S A, 2012 Dec 18. PMID 23213226, Free PMC Article
    4. Functions of SMC2 in the Development of Zebrafish Liver. Li X, et al. Biomedicines, 2021 Sep 16. PMID 34572426, Free PMC Article
    5. Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients. Mans DA, et al. J Pathol, 2013 Sep. PMID 23744542

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in condensed chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    structural maintenance of chromosomes protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199542.2 → NP_955836.2  structural maintenance of chromosomes protein 2

      Status: VALIDATED

      Source sequence(s)
      BX548248
      UniProtKB/TrEMBL
      A0A8M1PBH0, B8A5K9, E7F2I1
      Related
      ENSDARP00000104167.3, ENSDART00000109416.4
      Conserved Domains (6) summary
      pfam06673
      Location:252 → 465
      L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
      cd03273
      Location:1 → 156
      ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
      smart00968
      Location:522 → 639
      SMC_hinge; SMC proteins Flexible Hinge Domain
      COG1196
      Location:1 → 1170
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13863
      Location:740 → 841
      DUF4200; Domain of unknown function (DUF4200)
      cl21455
      Location:1074 → 1169
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      19538299..19561801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394474.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      75483..98985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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