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    napsa napsin A aspartic peptidase [ Danio rerio (zebrafish) ]

    Gene ID: 336746, updated on 28-Oct-2024

    Summary

    Official Symbol
    napsaprovided by ZNC
    Official Full Name
    napsin A aspartic peptidaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8690
    See related
    Ensembl:ENSDARG00000009313 AllianceGenome:ZFIN:ZDB-GENE-030131-8690
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa94d12; zgc:63831; wu:fa94d12
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space and lysosome. Orthologous to human NAPSA (napsin A aspartic peptidase). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See napsa in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (25121365..25133244)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (24990817..25002696)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene chondroadherin-like a Neighboring gene mitochondrial elongation factor 1 Neighboring gene si:ch211-256m1.8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200031.1NP_956325.1  napsin-A precursor

      See identical proteins and their annotated locations for NP_956325.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056836
      UniProtKB/TrEMBL
      Q6PGT7
      Related
      ENSDARP00000012342.6, ENSDART00000025724.7
      Conserved Domains (3) summary
      cd05490
      Location:86410
      Cathepsin_D2; Cathepsin_D2, pepsin family of proteinases
      pfam00026
      Location:91411
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:2148
      A1_Propeptide; A1 Propeptide

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      25121365..25133244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)