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    APP amyloid beta precursor protein [ Homo sapiens (human) ]

    Gene ID: 351, updated on 29-Oct-2024

    Summary

    Official Symbol
    APPprovided by HGNC
    Official Full Name
    amyloid beta precursor proteinprovided by HGNC
    Primary source
    HGNC:HGNC:620
    See related
    Ensembl:ENSG00000142192 MIM:104760; AllianceGenome:HGNC:620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma; alpha-sAPP
    Summary
    This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in brain (RPKM 395.2), kidney (RPKM 282.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See APP in Genome Data Viewer
    Location:
    21q21.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (25880550..26171128, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (24238622..24529258, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (27252861..27543446, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372757 Neighboring gene uncharacterized LOC105372756 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27290380-27290953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27290954-27291526 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:27326978-27328177 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27333032-27333727 Neighboring gene RNA, U6 small nuclear 123, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18320 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:27360167-27360668 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27369694-27370507 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27370508-27371320 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:27395669-27396168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27451148-27451673 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:27452711-27453576 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27453577-27454444 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27454445-27455310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27456082-27456619 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:27479739-27480384 Neighboring gene uncharacterized LOC124900466 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:27511930-27513129 Neighboring gene NANOG hESC enhancer GRCh37_chr21:27521254-27521823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13235 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:27542299-27542823 Neighboring gene APP divergent transcript Neighboring gene RNA, U6 small nuclear 926, pseudogene Neighboring gene myristoylated alanine rich protein kinase C substrate pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Alzheimer disease
    MedGen: C0002395 GeneReviews: Alzheimer Disease Overview
    Compare labs
    Alzheimer disease type 1
    MedGen: C1863052 OMIM: 104300 GeneReviews: Alzheimer Disease Overview
    Compare labs
    Cerebral amyloid angiopathy, APP-related
    MedGen: C2751536 OMIM: 605714 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2024-06-03)

    ClinGen Genome Curation Page
    Triplosensitivity

    Sufficient evidence for dosage pathogenicity (Last evaluated 2024-06-03)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced upregulation of APP protein production involves JNK MAPK signaling pathway in human cells PubMed
    env Transgenic (tg) mice overexpressing both human amyloid precursor proteins and HIV-1 gp120 at moderate levels show significantly less neuronal loss, synapto-dendritic degeneration, and gliosis than singly tg mice expressing gp120 alone PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 Env is identified to have a physical interaction with amyloid beta (A4) precursor protein (APP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope transmembrane glycoprotein gp41 env A putative immunosuppressive domain (amino acids 583-599) of HIV-1 gp41 downregulates the interleukin 1beta- (IL-1beta) induced elevation of the secreted form of APP (sAPP alpha) PubMed
    Tat tat HIV-1 Tat increases secreted and intracellular levels of APP (Ab); increases are dependent upon Tat amino acids 31-61 and can be inhibited by caffeine PubMed
    tat HIV-1 Tat recruits APP into lipid rafts to facilitate the processing of APP by beta-secretase, which leads to increased levels of ABeta42 in HIV-1 infected U-87 MG cells PubMed
    tat HIV-1 Tat co-localizes with APP and promotes localization of APP to lipid rafts with flotillin-1 in HIV-1 infected U-87 MG cells PubMed
    tat Immunoprecipitation assay demonstrates that HIV-1 Tat directly interacts with APP and the cysteine-rich domain (residues 21-37) of Tat is required to APP binding in U-87 MG cells PubMed
    tat HIV-1 Tat treatment results in a 125% increase in soluble amyloid beta (Abeta) in brain cultures PubMed
    tat Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein PubMed
    retropepsin gag-pol HIV-1 protease cleaves amyloid protein precursor at amino acid sites 200-201, 229-230, and 535-536 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables PTB domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RAGE receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetylcholine receptor activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables acetylcholine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables amylin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables apolipoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chemoattractant activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables chromatin binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables frizzled binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heparan sulfate binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables heparan sulfate proteoglycan binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables low-density lipoprotein particle receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in NMDA selective glutamate receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in adult locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in amyloid fibril formation EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in amyloid fibril formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antifungal humoral response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in associative learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in astrocyte activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in astrocyte activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in astrocyte activation involved in immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in axo-dendritic transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axon midline choice point recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amyloid-beta IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to amyloid-beta IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT involved_in chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cognition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in collateral sprouting in absence of injury ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytosolic mRNA polyadenylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in extracellular matrix organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular copper ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ionotropic glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning or memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipoprotein metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in low-density lipoprotein particle mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mating behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in microglia development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in microglial cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microglial cell activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in modulation of excitatory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of blood circulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of gene expression TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of miRNA transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of presynapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein localization to nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron cellular homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuron projection maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuron remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_positive_effect phospholipase D-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of G protein-coupled receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of T cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Toll signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of amyloid fibril formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of amyloid precursor protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cAMP/PKA signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of calcium-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of chemokine production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of endothelin production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of excitatory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of gene expression, epigenetic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of glycolytic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of monocyte chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of protein import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of superoxide anion generation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of type II interferon production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein homooligomerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in protein tetramerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein tetramerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in protein trimerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein trimerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in regulation of Wnt signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of amyloid fibril formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of regulation of amyloid-beta clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of dendritic spine maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of long-term neuronal synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of multicellular organism growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neurotransmitter uptake IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of peptidyl-tyrosine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of presynapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of spontaneous synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of synapse structure or activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of toll-like receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in response to auditory stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to interleukin-1 ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to yeast IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in suckling behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synapse organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in synaptic assembly at neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in visual learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    located_in Golgi-associated vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of amyloid-beta complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of amyloid-beta complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of amyloid-beta complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cell surface NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary rootlet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    NOT colocalizes_with dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT colocalizes_with dendrite membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT colocalizes_with dendrite membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome lumen TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endosome to plasma membrane transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    part_of high-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of high-density lipoprotein particle IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of intermediate-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of intermediate-density lipoprotein particle IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of low-density lipoprotein particle IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    colocalizes_with lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     
    colocalizes_with postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in smooth endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle midzone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT colocalizes_with synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
     
    part_of very-low-density lipoprotein particle IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    amyloid-beta precursor protein
    Names
    alzheimer disease amyloid A4 protein homolog
    alzheimer disease amyloid protein
    amyloid beta (A4) precursor protein
    amyloid beta A4 protein
    amyloid precursor protein
    beta-amyloid peptide
    beta-amyloid peptide(1-40)
    beta-amyloid peptide(1-42)
    beta-amyloid precursor protein
    cerebral vascular amyloid peptide
    peptidase nexin-II
    protease nexin-II
    testicular tissue protein Li 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007376.2 RefSeqGene

      Range
      5359..295579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000484.4NP_000475.1  amyloid-beta precursor protein isoform a precursor

      See identical proteins and their annotated locations for NP_000475.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as PreA4 770).
      Source sequence(s)
      AK312326, BC065529, BI559391, BM876312
      Consensus CDS
      CCDS13576.1
      UniProtKB/Swiss-Prot
      B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P05067, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q6GSC0, Q8WZ99, Q9BT38, Q9UC33, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58
      UniProtKB/TrEMBL
      A0A140VJC8, A0A218KGR2
      Related
      ENSP00000284981.4, ENST00000346798.8
      Conserved Domains (5) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294341
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam03494
      Location:677713
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:716766
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:366548
      APP_E2; E2 domain of amyloid precursor protein
    2. NM_001136016.3NP_001129488.1  amyloid-beta precursor protein isoform d

      See identical proteins and their annotated locations for NP_001129488.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform a.
      Source sequence(s)
      AK295621, AK311717, BM876312, Y00264
      Consensus CDS
      CCDS56212.1
      UniProtKB/TrEMBL
      A0A218KGR2
      Related
      ENSP00000387483.2, ENST00000440126.7
      Conserved Domains (7) summary
      smart00006
      Location:19183
      A4_EXTRA; amyloid A4
      pfam00014
      Location:289337
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:26126
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:651689
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:692742
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:128183
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:342524
      APP_E2; E2 domain of amyloid precursor protein
    3. NM_001136129.3NP_001129601.1  amyloid-beta precursor protein isoform e precursor

      See identical proteins and their annotated locations for NP_001129601.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AF282245, BC065529, BI559391, BM876312
      Consensus CDS
      CCDS46638.1
      UniProtKB/TrEMBL
      B4DQM1
      Related
      ENSP00000346129.3, ENST00000354192.7
      Conserved Domains (4) summary
      pfam03494
      Location:544582
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:585635
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:235417
      APP_E2; E2 domain of amyloid precursor protein
      cl26273
      Location:19132
      APP_N; Amyloid A4 N-terminal heparin-binding
    4. NM_001136130.3NP_001129602.1  amyloid-beta precursor protein isoform f precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (f) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK294534, BC065523, BC065529, BI559391, BM876312
      Consensus CDS
      CCDS46639.1
      UniProtKB/TrEMBL
      B4DGD0, E9PG40
      Related
      ENSP00000398879.2, ENST00000439274.6
      Conserved Domains (6) summary
      pfam00014
      Location:238286
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:1975
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:619657
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:660710
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:77132
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:310492
      APP_E2; E2 domain of amyloid precursor protein
    5. NM_001136131.3NP_001129603.1  amyloid-beta precursor protein isoform g

      See identical proteins and their annotated locations for NP_001129603.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (g) is shorter at the N-terminus and lacks an internal segment compared to isoform a.
      Source sequence(s)
      AK296229, BM876312, Y00264
      Consensus CDS
      CCDS56211.1
      UniProtKB/TrEMBL
      A0A0A0MRG2, B4DJT9
      Related
      ENSP00000352760.4, ENST00000359726.7
      Conserved Domains (4) summary
      smart00006
      Location:1153
      A4_EXTRA; amyloid A4
      pfam03494
      Location:565603
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:606656
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:256438
      APP_E2; E2 domain of amyloid precursor protein
    6. NM_001204301.2NP_001191230.1  amyloid-beta precursor protein isoform h precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (h, also known as L-APP752) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications.
      Source sequence(s)
      AK294534, AK312326, BI559391, BM876312, Y00264
      Consensus CDS
      CCDS56213.1
      UniProtKB/TrEMBL
      A0A218KGR2
      Related
      ENSP00000351796.3, ENST00000358918.7
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:657695
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:698748
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:366548
      APP_E2; E2 domain of amyloid precursor protein
    7. NM_001204302.2NP_001191231.1  amyloid-beta precursor protein isoform i precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (i, also known as L-APP733) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications.
      Source sequence(s)
      BI559391, BM876312, X06989, Y00264
      UniProtKB/TrEMBL
      A0A218KGR2
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:638676
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:679729
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347529
      APP_E2; E2 domain of amyloid precursor protein
    8. NM_001204303.2NP_001191232.1  amyloid-beta precursor protein isoform j precursor

      See identical proteins and their annotated locations for NP_001191232.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (j, also known as L-APP677) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications.
      Source sequence(s)
      BI559391, BM876312, Y00264
      UniProtKB/TrEMBL
      B4DQM1
      Conserved Domains (3) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam12925
      Location:291473
      APP_E2; E2 domain of amyloid precursor protein
      cl41775
      Location:600674
      JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins
    9. NM_001385253.1NP_001372182.1  amyloid-beta precursor protein isoform k precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (k) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AP001439, AP001440, AP001441, AP001442, AP001443, KC877827
      UniProtKB/TrEMBL
      B4DQM1
      Conserved Domains (3) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam12925
      Location:310492
      APP_E2; E2 domain of amyloid precursor protein
      cl41775
      Location:637711
      JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins
    10. NM_201413.3NP_958816.1  amyloid-beta precursor protein isoform b precursor

      See identical proteins and their annotated locations for NP_958816.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as PreA4 751) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC065529, BI559391, BM876312
      Consensus CDS
      CCDS33523.1
      UniProtKB/TrEMBL
      A0A218KGR2
      Related
      ENSP00000350578.3, ENST00000357903.7
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:656694
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:697747
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347529
      APP_E2; E2 domain of amyloid precursor protein
    11. NM_201414.3NP_958817.1  amyloid-beta precursor protein isoform c precursor

      See identical proteins and their annotated locations for NP_958817.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c, also known as PreA4 695) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BI559391, BM876312, Y00264
      Consensus CDS
      CCDS13577.1
      UniProtKB/TrEMBL
      B4DQM1
      Related
      ENSP00000345463.5, ENST00000348990.9
      Conserved Domains (3) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam12925
      Location:291473
      APP_E2; E2 domain of amyloid precursor protein
      cl41775
      Location:618692
      JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      25880550..26171128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      24238622..24529258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)