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    tlr9 toll-like receptor 9 [ Danio rerio (zebrafish) ]

    Gene ID: 403128, updated on 28-Oct-2024

    Summary

    Official Symbol
    tlr9provided by ZNC
    Official Full Name
    toll-like receptor 9provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040219-10
    See related
    Ensembl:ENSDARG00000044490 AllianceGenome:ZFIN:ZDB-GENE-040219-10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu392
    Summary
    Predicted to enable pattern recognition receptor activity. Acts upstream of or within antibacterial humoral response and toll-like receptor signaling pathway. Located in endoplasmic reticulum. Is expressed in several structures, including blood; eye; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See tlr9 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (53730368..53733659, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (53900648..53903939, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family, member 5a Neighboring gene ELKS/RAB6-interacting/CAST family member 2 Neighboring gene acylaminoacyl-peptide hydrolase Neighboring gene bassoon presynaptic cytomatrix protein a

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    toll-like receptor 9
    Names
    TIR9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130594.1NP_001124066.1  toll-like receptor 9 precursor

      See identical proteins and their annotated locations for NP_001124066.1

      Status: PROVISIONAL

      Source sequence(s)
      BC163628
      UniProtKB/TrEMBL
      B3DJW3
      Related
      ENSDARP00000105677.2, ENSDART00000124218.3
      Conserved Domains (4) summary
      cd00116
      Location:73312
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:3957
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:56129
      LRR_8; Leucine rich repeat
      cl23749
      Location:8941040
      TIR_2; TIR domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      53730368..53733659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)