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    acadm acyl-CoA dehydrogenase medium chain [ Danio rerio (zebrafish) ]

    Gene ID: 406283, updated on 12-Oct-2024

    Summary

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    Official Symbol
    acadmprovided by ZNC
    Official Full Name
    acyl-CoA dehydrogenase medium chainprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1945
    See related
    Ensembl:ENSDARG00000038900 AllianceGenome:ZFIN:ZDB-GENE-040426-1945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    MCAD; fb53e01; zgc:56101; zgc:76911; wu:fb53e01; zgc:111905
    Summary
    Predicted to enable medium-chain-acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation and medium-chain fatty acid catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in female organism and liver. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See acadm in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (26470070..26476119, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (26814436..26820485, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene ephrin-A2a Neighboring gene uncharacterized LOC137487824 Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene HECT domain containing 3 Neighboring gene small nucleolar RNA SNORD46 Neighboring gene ribosomal protein S8a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Inhibitory Effects of Mongolian Medicine Yihe-Tang on Continuous Darkness Induced Liver Steatosis in Zebrafish. Sa R, et al. Evid Based Complement Alternat Med, 2022. PMID 35646144, Free PMC Article
    2. Differential mitochondrial dysregulation by exposure to individual organochlorine pesticides (OCPs) and their mixture in zebrafish embryos. Lee H, et al. Environ Pollut, 2021 May 15. PMID 33714130
    3. Enantioselective bioaccumulation following exposure of adult zebrafish (Danio rerio) to epoxiconazole and its effects on metabolomic profile as well as genes expression. Wang Y, et al. Environ Pollut, 2017 Oct. PMID 28601015
    4. Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. Hasumura T, et al. Nutr Metab (Lond), 2012 Aug 7. PMID 22871059, Free PMC Article
    5. Temporal and spatial patterns of gene expression in skeletal muscles in response to swim training in adult zebrafish (Danio rerio). LeMoine CM, et al. J Comp Physiol B, 2010 Jan. PMID 19693513

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables medium-chain fatty acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in medium-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    medium-chain specific acyl-CoA dehydrogenase, mitochondrial
    Names
    acyl-CoA dehydrogenase, C-4 to C-12 straight chain
    acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
    NP_998175.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213010.2 → NP_998175.2  medium-chain specific acyl-CoA dehydrogenase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      DT082054, EB765156, EH563476, EH601638
      UniProtKB/TrEMBL
      A0A8M1PII2, A2CG95
      Related
      ENSDARP00000117024.1, ENSDART00000132125.3
      Conserved Domains (2) summary
      cd01157
      Location:46 → 423
      MCAD; Medium chain acyl-CoA dehydrogenase
      COG1960
      Location:44 → 426
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      26470070..26476119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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