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    MCM6 minichromosome maintenance complex component 6 [ Homo sapiens (human) ]

    Gene ID: 4175, updated on 28-Oct-2024

    Summary

    Official Symbol
    MCM6provided by HGNC
    Official Full Name
    minichromosome maintenance complex component 6provided by HGNC
    Primary source
    HGNC:HGNC:6949
    See related
    Ensembl:ENSG00000076003 MIM:601806; AllianceGenome:HGNC:6949
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Mis5; P105MCM; MCG40308
    Summary
    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
    Expression
    Broad expression in lymph node (RPKM 19.9), bone marrow (RPKM 13.7) and 24 other tissues See more
    Orthologs
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    Genomic context

    See MCM6 in Genome Data Viewer
    Location:
    2q21.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (135839626..135876443, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (136284082..136320862, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (136597196..136634013, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16577 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:136499891-136500666 Neighboring gene UBX domain protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:136554979-136555500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:136555501-136556024 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:136574960-136576159 Neighboring gene lactase Neighboring gene LCT antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:136633103-136633638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:136656467-136656966 Neighboring gene MANEAL pseudogene 1 Neighboring gene uncharacterized LOC124906078 Neighboring gene aspartyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with minichromosome maintenance complex component 6 (MCM6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of minichromosome maintenance complex component 6 (MCM6) in the nucleoli of Jurkat T-cells PubMed
    tat Interaction of HIV-1 Tat with MCM6 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
    Vpr vpr HIV-1 Vpr downregulates MCM6 in HeLa cells within 12 hours of exposure PubMed
    integrase gag-pol HIV-1 IN is identified to have a physical interaction with minichromosome maintenance complex component 6 (MCM6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to single-stranded 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA replication NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA unwinding involved in DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of DNA-templated DNA replication initiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CMG complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of CMG complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of MCM complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MCM complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromosome, telomeric region HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA replication licensing factor MCM6
    Names
    MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
    minichromosome maintenance deficient (mis5, S. pombe) 6
    NP_005906.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008958.1 RefSeqGene

      Range
      4999..41816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005915.6NP_005906.2  DNA replication licensing factor MCM6

      See identical proteins and their annotated locations for NP_005906.2

      Status: REVIEWED

      Source sequence(s)
      AA577398, BC020268, BC032374, CN389677, DA521248
      Consensus CDS
      CCDS2179.1
      UniProtKB/Swiss-Prot
      B2R6H2, Q13504, Q14566, Q99859
      UniProtKB/TrEMBL
      Q4ZG57
      Related
      ENSP00000264156.2, ENST00000264156.3
      Conserved Domains (3) summary
      smart00350
      Location:119657
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:27114
      MCM_N; MCM N-terminal domain
      pfam18263
      Location:713817
      MCM6_C; MCM6 C-terminal winged-helix domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      135839626..135876443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      136284082..136320862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)