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    pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [ Danio rerio (zebrafish) ]

    Gene ID: 557176, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pik3r1provided by ZNC
    Official Full Name
    phosphoinositide-3-kinase, regulatory subunit 1 (alpha)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1280
    See related
    Ensembl:ENSDARG00000038524 AllianceGenome:ZFIN:ZDB-GENE-030131-1280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb65b05
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; and regulation of phosphatidylinositol 3-kinase activity. Predicted to act upstream of or within signal transduction. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in eye and male organism. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; astroblastoma; endometrial cancer (multiple); immunodeficiency 36; and type 2 diabetes mellitus. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See pik3r1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (54767133..54792242, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (54144297..54169406, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495524 Neighboring gene solute carrier family 30 member 5 Neighboring gene CD180 molecule Neighboring gene microtubule associated serine/threonine kinase family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Receptor-Mediated AKT/PI3K Signalling and Behavioural Alterations in Zebrafish Larvae Reveal Association between Schizophrenia and Opioid Use Disorder. Thiagarajan SK, et al. Int J Mol Sci, 2022 Apr 25. PMID 35563106, Free PMC Article
    2. Deciphering combinations of PI3K/AKT/mTOR pathway drugs augmenting anti-angiogenic efficacy in vivo. Sasore T, et al. PLoS One, 2014. PMID 25144531, Free PMC Article
    3. Leucine mediates autophagosome-lysosome fusion and improves sperm motility by activating the PI3K/Akt pathway. Zhang J, et al. Oncotarget, 2017 Dec 19. PMID 29340093, Free PMC Article
    4. Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish. Mazumder AG, et al. Epilepsy Res, 2019 Nov. PMID 31563029
    5. Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures. Tanwar G, et al. Sci Rep, 2019 May 27. PMID 31133639, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex, class IA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit alpha
    Names
    phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281844.1 → NP_001268773.1  phosphatidylinositol 3-kinase regulatory subunit alpha

      Status: VALIDATED

      Source sequence(s)
      BX571667
      UniProtKB/TrEMBL
      A0A8M1P036, B0S6V7, E7FED3
      Related
      ENSDARP00000056212.4, ENSDART00000056213.6
      Conserved Domains (6) summary
      cd09930
      Location:620 → 722
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:329 → 436
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11910
      Location:5 → 79
      SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12924
      Location:441 → 601
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      cd04388
      Location:114 → 303
      RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...
      pfam16454
      Location:440 → 599
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      54767133..54792242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165663.5 → XP_005165720.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A8M2BCX6
      Conserved Domains (4) summary
      cd09930
      Location:319 → 421
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:28 → 135
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:140 → 300
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      pfam16454
      Location:139 → 298
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

    2. XM_005165664.5 → XP_005165721.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A8M2BCY4
      Conserved Domains (4) summary
      cd09930
      Location:298 → 400
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:4 → 114
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:119 → 279
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      pfam16454
      Location:118 → 277
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

    3. XM_005165662.5 → XP_005165719.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M2BD59, B0S6V6, E7FB59
      Related
      ENSDARP00000106578.2, ENSDART00000122829.3
      Conserved Domains (4) summary
      cd09930
      Location:342 → 444
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:51 → 158
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:163 → 323
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      pfam16454
      Location:162 → 321
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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