trioa trio Rho guanine nucleotide exchange factor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trioaprovided by ZNC
Official Full Name: trio Rho guanine nucleotide exchange factor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-334
See related: Ensembl:ENSDARG00000019426 AllianceGenome:ZFIN:ZDB-GENE-060503-334
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: trio; si:ch211-13c6.1; si:dkey-158b13.2
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance. Predicted to act upstream of or within central nervous system development and protein phosphorylation. Predicted to be active in cytoplasm. Predicted to be extrinsic component of membrane. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability and autosomal dominant non-syndromic intellectual disability 44. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 59

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (41840964..41991299, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (42255971..42460198, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo.
Title: Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: triple functional domain protein

Names: triple functional domain (PTPRF interacting)

NP_001097996.1

EC 2.7.11.1

XP_009292696.1

EC 2.7.11.1

XP_017207732.1

EC 2.7.11.1

XP_021323750.1

EC 2.7.11.1

XP_021323751.1

EC 2.7.11.1

XP_021323752.1

EC 2.7.11.1

XP_021323753.1

EC 2.7.11.1

XP_021323754.1

EC 2.7.11.1

XP_021323755.1

EC 2.7.11.1

XP_021323756.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001104526.1 → NP_001097996.1 triple functional domain protein

Status: PROVISIONAL

Source sequence(s)

BX950864, BX957244

UniProtKB/Swiss-Prot

Q1LUA6

UniProtKB/TrEMBL

A0A8M1NFT5, F1Q551

Related

ENSDARP00000081489.4, ENSDART00000087055.6

Conserved Domains (13) summary

cd11852
Location:1668 → 1727

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2543 → 2601

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2785 → 3039

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:69 → 207

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1303 → 1475

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:577 → 793

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2674 → 2765

I-set; Immunoglobulin I-set domain

cd13240
Location:1482 → 1604

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2158 → 2297

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1983 → 2154

RhoGEF; RhoGEF domain

pfam16609
Location:1724 → 1982

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl11960
Location:2691 → 2765

Ig; Immunoglobulin domain

cl21453
Location:2777 → 3039

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

41840964..41991299 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468076.1 → XP_021323751.1 triple functional domain protein isoform X2

UniProtKB/Swiss-Prot

Q1LUA6

UniProtKB/TrEMBL

A0A8M9PNC1

Conserved Domains (12) summary

smart00150
Location:1166 → 1266

SPEC; Spectrin repeats

cd11852
Location:1695 → 1754

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2570 → 2628

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:61 → 199

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:2007 → 2180

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:590 → 806

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2701 → 2792

I-set; Immunoglobulin I-set domain

cd13240
Location:1495 → 1627

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2185 → 2324

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam16609
Location:1752 → 2000

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl21453
Location:2804 → 3066

PKc_like; Protein Kinases, catalytic domain

cl26464
Location:2364 → 2523

Atrophin-1; Atrophin-1 family
XM_021468077.1 → XP_021323752.1 triple functional domain protein isoform X3

UniProtKB/Swiss-Prot

Q1LUA6

UniProtKB/TrEMBL

A0A8M9P1U8

Conserved Domains (12) summary

smart00150
Location:1166 → 1266

SPEC; Spectrin repeats

cd11852
Location:1695 → 1754

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2570 → 2628

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:61 → 199

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:2007 → 2180

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:590 → 806

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2698 → 2789

I-set; Immunoglobulin I-set domain

cd13240
Location:1495 → 1627

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2185 → 2324

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam16609
Location:1752 → 2000

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl21453
Location:2801 → 3063

PKc_like; Protein Kinases, catalytic domain

cl26464
Location:2364 → 2523

Atrophin-1; Atrophin-1 family
XM_009294421.3 → XP_009292696.1 triple functional domain protein isoform X8

UniProtKB/Swiss-Prot

Q1LUA6

UniProtKB/TrEMBL

A0A8M3ASV0

Conserved Domains (13) summary

cd11852
Location:1664 → 1723

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2539 → 2597

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2781 → 3035

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:61 → 199

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1295 → 1467

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:569 → 785

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2670 → 2761

I-set; Immunoglobulin I-set domain

cd13240
Location:1474 → 1596

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2154 → 2293

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1979 → 2150

RhoGEF; RhoGEF domain

pfam16609
Location:1720 → 1978

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl11960
Location:2687 → 2761

Ig; Immunoglobulin domain

cl21453
Location:2773 → 3035

PKc_like; Protein Kinases, catalytic domain
XM_021468075.1 → XP_021323750.1 triple functional domain protein isoform X1

UniProtKB/Swiss-Prot

Q1LUA6

UniProtKB/TrEMBL

A0A8M9PRK6

Conserved Domains (12) summary

smart00150
Location:1166 → 1266

SPEC; Spectrin repeats

cd11852
Location:1695 → 1754

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2570 → 2628

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:61 → 199

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:2007 → 2180

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:590 → 806

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2702 → 2793

I-set; Immunoglobulin I-set domain

cd13240
Location:1495 → 1627

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2185 → 2324

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam16609
Location:1752 → 2000

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cl21453
Location:2805 → 3067

PKc_like; Protein Kinases, catalytic domain

cl26464
Location:2364 → 2523

Atrophin-1; Atrophin-1 family
XM_021468079.1 → XP_021323754.1 triple functional domain protein isoform X5

UniProtKB/TrEMBL

A0A8M9PGG0

Conserved Domains (8) summary

smart00150
Location:1166 → 1266

SPEC; Spectrin repeats

cd11852
Location:1695 → 1754

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:61 → 199

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:2007 → 2180

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:590 → 806

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1495 → 1627

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2185 → 2316

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam16609
Location:1752 → 2000

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_021468078.1 → XP_021323753.1 triple functional domain protein isoform X4

UniProtKB/TrEMBL

A0A8M9PAZ8

Conserved Domains (8) summary

smart00150
Location:1166 → 1266

SPEC; Spectrin repeats

cd11852
Location:1695 → 1754

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:61 → 199

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:2007 → 2180

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:590 → 806

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1495 → 1627

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2185 → 2324

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam16609
Location:1752 → 2000

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_017352243.2 → XP_017207732.1 triple functional domain protein isoform X9

UniProtKB/TrEMBL

A0A8M6Z2C9
XM_021468081.1 → XP_021323756.1 triple functional domain protein isoform X7

UniProtKB/TrEMBL

A0A8M9PNC8

Conserved Domains (7) summary

smart00150
Location:1166 → 1266

SPEC; Spectrin repeats

cd11852
Location:1695 → 1754

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:61 → 199

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1316 → 1488

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:590 → 806

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1495 → 1627

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

pfam16609
Location:1752 → 1926

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_021468080.1 → XP_021323755.1 triple functional domain protein isoform X6

UniProtKB/TrEMBL

A0A8M9PRL6

Conserved Domains (7) summary

smart00150
Location:1166 → 1266

SPEC; Spectrin repeats

cd11852
Location:1695 → 1754

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:61 → 199

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1316 → 1488

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:590 → 806

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1495 → 1627

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

pfam16609
Location:1752 → 1926

SH3-RhoG_link; SH3-RhoGEF linking unstructured region