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    vegfab vascular endothelial growth factor Ab [ Danio rerio (zebrafish) ]

    Gene ID: 558154, updated on 2-Nov-2024

    Summary

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    Official Symbol
    vegfabprovided by ZNC
    Official Full Name
    vascular endothelial growth factor Abprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4605
    See related
    Ensembl:ENSDARG00000034700 AllianceGenome:ZFIN:ZDB-GENE-030131-4605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd42e02; wu:fd42e02; si:dkey-14d8.3
    Summary
    Predicted to enable chemoattractant activity; growth factor activity; and vascular endothelial growth factor receptor binding activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in brain; head; pronephros; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See vegfab in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (5587169..5597847, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (5578598..5589519, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:dkey-14d8.6 Neighboring gene si:dkey-14d8.7 Neighboring gene mitochondrial ribosomal protein S18A Neighboring gene radial spoke head component 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Preliminary safety assessment of oridonin in zebrafish. Tian L, et al. Pharm Biol, 2019 Dec. PMID 31545911, Free PMC Article
    2. Functional inhibition of UQCRB suppresses angiogenesis in zebrafish. Cho YS, et al. Biochem Biophys Res Commun, 2013 Apr 19. PMID 23454382, Free PMC Article
    3. Ocular vessel patterning in zebrafish is indirectly regulated by Hedgehog signaling. Weiss O, et al. Int J Dev Biol, 2017. PMID 28621424
    4. Gamma radiation induces locus specific changes to histone modification enrichment in zebrafish and Atlantic salmon. Lindeman LC, et al. PLoS One, 2019. PMID 30759148, Free PMC Article
    5. Overexpression of preeclampsia induced microRNA-26a-5p leads to proteinuria in zebrafish. Müller-Deile J, et al. Sci Rep, 2018 Feb 26. PMID 29483572, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vascular endothelial growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in induction of positive chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mast cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vascular endothelial growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vascular endothelial growth factor Ab

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328597.1 → NP_001315526.1  vascular endothelial growth factor Ab isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX324164
      UniProtKB/TrEMBL
      A0A8M1P9F8
      Related
      ENSDARP00000120079.1, ENSDART00000132431.3
      Conserved Domains (2) summary
      pfam14554
      Location:204 → 252
      VEGF_C; VEGF heparin-binding domain
      pfam00341
      Location:49 → 127
      PDGF; PDGF/VEGF domain

    2. NM_001328598.1 → NP_001315527.1  vascular endothelial growth factor Ab isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BX324164, DQ150576
      UniProtKB/TrEMBL
      Q0QYI0
      Related
      ENSDARP00000120175.1, ENSDART00000136229.2
      Conserved Domains (2) summary
      pfam14554
      Location:146 → 194
      VEGF_C; VEGF heparin-binding domain
      pfam00341
      Location:49 → 127
      PDGF; PDGF/VEGF domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      5587169..5597847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299968.4 → XP_009298243.1  vascular endothelial growth factor Ab isoform X4

      UniProtKB/TrEMBL
      A0A8M3B1G0
      Conserved Domains (3) summary
      PHA02661
      Location:42 → 170
      PHA02661; vascular endothelial growth factor like protein; Provisional
      pfam00341
      Location:83 → 161
      PDGF; PDGF/VEGF domain
      pfam14554
      Location:172 → 227
      VEGF_C; VEGF heparin-binding domain

    2. XM_068219654.1 → XP_068075755.1  vascular endothelial growth factor Ab isoform X3

    3. XM_005164518.5 → XP_005164575.1  vascular endothelial growth factor Ab isoform X2

      UniProtKB/TrEMBL
      A0A8M2BBS4
      Conserved Domains (3) summary
      PHA02661
      Location:42 → 170
      PHA02661; vascular endothelial growth factor like protein; Provisional
      pfam00341
      Location:83 → 161
      PDGF; PDGF/VEGF domain
      pfam14554
      Location:196 → 250
      VEGF_C; VEGF heparin-binding domain

    4. XM_068219653.1 → XP_068075754.1  vascular endothelial growth factor Ab isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001044855.2: Suppressed sequence

      Description
      NM_001044855.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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