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    nfs1 NFS1 cysteine desulfurase [ Danio rerio (zebrafish) ]

    Gene ID: 562714, updated on 12-Sep-2024

    Summary

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    Official Symbol
    nfs1provided by ZNC
    Official Full Name
    NFS1 cysteine desulfuraseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060405-1
    See related
    Ensembl:ENSDARG00000062237 AllianceGenome:ZFIN:ZDB-GENE-060405-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb50g03; wu:fb50g03
    Summary
    Predicted to enable cysteine desulfurase activity. Predicted to be involved in iron-sulfur cluster assembly. Predicted to act upstream of or within [2Fe-2S] cluster assembly. Predicted to be active in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human NFS1 (NFS1 cysteine desulfurase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See nfs1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (24348425..24356065)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (24110809..24118449)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch211-15p9.2 Neighboring gene RNA binding motif protein 39a Neighboring gene dishevelled segment polarity protein 1b Neighboring gene uncharacterized LOC137496651 Neighboring gene matrix-remodelling associated 8a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. pnp4a Is the Causal Gene of the Medaka Iridophore Mutant guanineless. Kimura T, et al. G3 (Bethesda), 2017 Apr 3. PMID 28258112, Free PMC Article
    2. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine desulfurase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine desulfurase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within [2Fe-2S] cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cysteine desulfurase
    Names
    NFS1 nitrogen fixation 1
    NP_001038458.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044993.1 → NP_001038458.1  cysteine desulfurase

      Status: PROVISIONAL

      Source sequence(s)
      BX001056
      UniProtKB/TrEMBL
      A4IG85, Q1LYQ9
      Related
      ENSDARP00000084180.5, ENSDART00000089747.7
      Conserved Domains (2) summary
      PRK14012
      Location:52 → 451
      PRK14012; cysteine desulfurase; Provisional
      pfam00266
      Location:54 → 415
      Aminotran_5; Aminotransferase class-V

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      24348425..24356065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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