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    Milr1 mast cell immunoglobulin-like receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59105, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Milr1provided by RGD
    Official Full Name
    mast cell immunoglobulin-like receptor 1provided by RGD
    Primary source
    RGD:620488
    See related
    EnsemblRapid:ENSRNOG00000042524 AllianceGenome:RGD:620488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mca32
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in several processes, including cell-cell adhesion via plasma-membrane adhesion molecules; mast cell degranulation; and negative regulation of mast cell activation. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human MILR1 (mast cell immunoglobulin like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 38.5), Spleen (RPKM 28.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Milr1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (92184002..92205001)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91684288..91705284)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94944243..94961795)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 83 Neighboring gene testis expressed 2 Neighboring gene platelet and endothelial cell adhesion molecule 1 Neighboring gene DNA polymerase gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene DEAD-box helicase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel surface antigen gene induced in mast cells activated through the high affinity IgE receptor. Pirozzi G, et al. J Immunol, 1995 Dec 15. PMID 7499870
    2. An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Hitomi K, et al. Nat Immunol, 2010 Jul. PMID 20526344
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mast cell degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mast cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    allergin-1
    Names
    MCA-32
    allergy inhibitory receptor 1
    mast cell Ag-32
    mast cell antigen 32
    surface protein MCA-32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410245.1 → NP_001397174.1  allergin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    2. NM_021585.1 → NP_067596.1  allergin-1 isoform 1

      See identical proteins and their annotated locations for NP_067596.1

      Status: VALIDATED

      Source sequence(s)
      U39546
      UniProtKB/TrEMBL
      A0A0G2K456, A6HK54
      Related
      ENSRNOP00000072914.2, ENSRNOT00000078968.3
      Conserved Domains (2) summary
      smart00410
      Location:82 → 151
      IG_like; Immunoglobulin like
      pfam13895
      Location:74 → 158
      Ig_2; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      92184002..92205001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086732.2 → XP_038942660.1  allergin-1 isoform X8

      Conserved Domains (1) summary
      smart00409
      Location:3 → 72
      IG; Immunoglobulin

    2. XM_039086730.2 → XP_038942658.1  allergin-1 isoform X8

      Conserved Domains (1) summary
      smart00409
      Location:3 → 72
      IG; Immunoglobulin

    3. XM_039086729.2 → XP_038942657.1  allergin-1 isoform X8

      Conserved Domains (1) summary
      smart00409
      Location:3 → 72
      IG; Immunoglobulin

    4. XM_039086731.2 → XP_038942659.1  allergin-1 isoform X8

      Conserved Domains (1) summary
      smart00409
      Location:3 → 72
      IG; Immunoglobulin

    5. XM_017597497.3 → XP_017452986.1  allergin-1 isoform X3

      UniProtKB/TrEMBL
      A6HK55

    6. XM_039086726.2 → XP_038942654.1  allergin-1 isoform X4

      UniProtKB/TrEMBL
      A6HK55
      Conserved Domains (1) summary
      pfam13895
      Location:74 → 155
      Ig_2; Immunoglobulin domain

    7. XM_008768388.4 → XP_008766610.1  allergin-1 isoform X6

      UniProtKB/TrEMBL
      A6HK55
      Conserved Domains (2) summary
      smart00410
      Location:82 → 151
      IG_like; Immunoglobulin like
      pfam13895
      Location:74 → 158
      Ig_2; Immunoglobulin domain

    8. XM_039086725.2 → XP_038942653.1  allergin-1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K456, A6HK54
      Conserved Domains (1) summary
      pfam13895
      Location:74 → 155
      Ig_2; Immunoglobulin domain

    9. XM_008768389.4 → XP_008766611.1  allergin-1 isoform X7

      UniProtKB/TrEMBL
      A6HK55
      Conserved Domains (2) summary
      smart00410
      Location:82 → 151
      IG_like; Immunoglobulin like
      pfam13895
      Location:74 → 158
      Ig_2; Immunoglobulin domain

    10. XM_039086724.2 → XP_038942652.1  allergin-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K456, A6HK54
      Conserved Domains (1) summary
      pfam13895
      Location:74 → 155
      Ig_2; Immunoglobulin domain

    11. XM_039086733.2 → XP_038942661.1  allergin-1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2K456, A6HK54
      Conserved Domains (1) summary
      pfam13895
      Location:74 → 155
      Ig_2; Immunoglobulin domain

    12. XM_039086727.2 → XP_038942655.1  allergin-1 isoform X5

      UniProtKB/Swiss-Prot
      Q62875
      Conserved Domains (1) summary
      smart00409
      Location:30 → 99
      IG; Immunoglobulin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62875.2 GenPept UniProtKB/Swiss-Prot:Q62875

    Gene LinkOut

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