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    nitr2b novel immune-type receptor 2b [ Danio rerio (zebrafish) ]

    Gene ID: 60647, updated on 25-Apr-2024

    Summary

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    Official Symbol
    nitr2bprovided by ZNC
    Official Full Name
    novel immune-type receptor 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-001106-6
    See related
    Ensembl:ENSDARG00000000460 AllianceGenome:ZFIN:ZDB-GENE-001106-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nitr2; nitr2.1; nitr2.2; nitr2.3; nitr2.5; nitr2.8; nitr2.16; nitr2.21
    Summary
    Predicted to be involved in response to bacterium. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SIRPB2 (signal regulatory protein beta 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See nitr2b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (17442801..17446930)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (17190828..17194957)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene novel immune-type receptor 3d Neighboring gene novel immune-type receptor 2a Neighboring gene novel immune-type receptor 1a Neighboring gene novel immune-type receptor 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Resolution of the novel immune-type receptor gene cluster in zebrafish. Yoder JA, et al. Proc Natl Acad Sci U S A, 2004 Nov 2. PMID 15496470, Free PMC Article
    2. Evolution of the zebrafish model: from development to immunity and infectious disease. Phelps HA, et al. Zebrafish, 2005. PMID 18248169
    3. Developmental and tissue-specific expression of NITRs. Yoder JA, et al. Immunogenetics, 2010 Feb. PMID 20012603, Free PMC Article
    4. The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains. Desai S, et al. BMC Evol Biol, 2008 Jun 19. PMID 18565225, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    novel immune-type receptor 2b
    Names
    novel immune-type receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131649.2 → NP_571724.1  novel immune-type receptor 2b precursor

      See identical proteins and their annotated locations for NP_571724.1

      Status: VALIDATED

      Source sequence(s)
      CU179759
      UniProtKB/TrEMBL
      A0A8N7XJ55, B3DHG2, F1QT58, Q90Z92
      Related
      ENSDARP00000060382.4, ENSDART00000060383.5
      Conserved Domains (3) summary
      cd00099
      Location:29 → 129
      IgV; Immunoglobulin variable domain (IgV)
      smart00410
      Location:28 → 129
      IG_like; Immunoglobulin like
      cl11960
      Location:149 → 232
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      17442801..17446930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017356909.1 → XP_017212398.1  novel immune-type receptor 2b isoform X1

      UniProtKB/TrEMBL
      A0A8N7XJ55, B3DHG2, F1QT58, Q90Z92
      Conserved Domains (3) summary
      cd00099
      Location:29 → 129
      IgV; Immunoglobulin variable domain (IgV)
      smart00410
      Location:28 → 129
      IG_like; Immunoglobulin like
      cl11960
      Location:149 → 232
      Ig; Immunoglobulin domain

    2. XM_017356908.1 → XP_017212397.1  novel immune-type receptor 2b isoform X1

      UniProtKB/TrEMBL
      Q90Z92
      Conserved Domains (3) summary
      cd00099
      Location:29 → 129
      IgV; Immunoglobulin variable domain (IgV)
      smart00410
      Location:28 → 129
      IG_like; Immunoglobulin like
      cl11960
      Location:149 → 232
      Ig; Immunoglobulin domain

    3. XM_017356910.1 → XP_017212399.1  novel immune-type receptor 2b isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z7Q5

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394681.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      222168..225304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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