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    Ephx3 epoxide hydrolase 3 [ Mus musculus (house mouse) ]

    Gene ID: 71932, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ephx3provided by MGI
    Official Full Name
    epoxide hydrolase 3provided by MGI
    Primary source
    MGI:MGI:1919182
    See related
    Ensembl:ENSMUSG00000037577 AllianceGenome:MGI:1919182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EH3; Abhd9; 2310063B19Rik
    Summary
    Predicted to enable epoxide hydrolase activity. Predicted to be involved in epoxide metabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human EPHX3 (epoxide hydrolase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in stomach adult (RPKM 8.4), lung adult (RPKM 2.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ephx3 in Genome Data Viewer
    Location:
    17 B1; 17 17.39 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32402742..32408444, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32183770..32189470, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38585 Neighboring gene notch 3 Neighboring gene predicted gene, 41568 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32301287-32301488 Neighboring gene VISTA enhancer mm1733 Neighboring gene bromodomain containing 4 Neighboring gene predicted gene 4432 Neighboring gene STARR-positive B cell enhancer ABC_E11795 Neighboring gene STARR-positive B cell enhancer ABC_E5590 Neighboring gene STARR-positive B cell enhancer ABC_E955 Neighboring gene A kinase anchor protein 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice. Hoopes SL, et al. PLoS One, 2017. PMID 28384353, Free PMC Article
    2. Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function. Edin ML, et al. J Biol Chem, 2021 Jan-Jun. PMID 33334892, Free PMC Article
    3. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Sirish P, et al. Proc Natl Acad Sci U S A, 2013 Apr 2. PMID 23493561, Free PMC Article
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function.
      Title: Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function.
    2. Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice
      Title: Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables epoxide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epoxide hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in epoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    epoxide hydrolase 3
    Names
    abhydrolase domain-containing protein 9
    NP_001028335.1
    NP_001334270.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033163.4 → NP_001028335.1  epoxide hydrolase 3 isoform 1

      See identical proteins and their annotated locations for NP_001028335.1

      Status: VALIDATED

      Source sequence(s)
      CT033755
      Consensus CDS
      CCDS28615.1
      UniProtKB/TrEMBL
      A0A0R4J127, A6H695
      Related
      ENSMUSP00000085013.4, ENSMUST00000087721.10
      Conserved Domains (2) summary
      COG0596
      Location:144 → 415
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:139 → 262
      Abhydrolase; alpha/beta hydrolases

    2. NM_001347341.2 → NP_001334270.1  epoxide hydrolase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT033755
      Consensus CDS
      CCDS84290.1
      UniProtKB/TrEMBL
      A6H695, G3XA19
      Related
      ENSMUSP00000124600.2, ENSMUST00000162117.3

    RNA

    1. NR_175782.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT033755

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      32402742..32408444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V1F8.2 GenPept UniProtKB/Swiss-Prot:Q3V1F8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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