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    PF3D7_1012600 GMP synthase [glutamine-hydrolyzing] [ Plasmodium falciparum 3D7 ]

    Gene ID: 810281, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1012600
    Gene description
    GMP synthase [glutamine-hydrolyzing]
    Locus tag
    PF3D7_1012600
    See related
    PlasmoDB:PF3D7_1012600; VEuPathDB:PF3D7_1012600
    Gene type
    protein coding
    RNA name
    GMP synthase [glutamine-hydrolyzing]
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1012600 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    1
    Sequence:
    Chromosome: 10; NC_037281.1 (482527..484194, complement)

    Chromosome 10 - NC_037281.1Genomic Context describing neighboring genes Neighboring gene hypoxanthine-guanine phosphoribosyltransferase Neighboring gene phosphoglucomutase, putative Neighboring gene NLI interacting factor-like phosphatase, putative Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037281.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation. Ballut L, et al. Nat Commun, 2015 Nov 23. PMID 26592566, Free PMC Article
    2. Kinetic and biochemical characterization of Plasmodium falciparum GMP synthetase. Bhat JY, et al. Biochem J, 2008 Jan 1. PMID 17868038
    3. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conformational changes in helix 371-375 of GMP synthetase holding catalytic residues and in loop 376-401 along the rotation trajectory trigger the different steps of catalysis
      Title: Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation.
    2. biochemical characterization of Plasmodium falciparum GMP synthetase
      Title: Kinetic and biochemical characterization of Plasmodium falciparum GMP synthetase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables GMP synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within purine nucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GMP synthase [glutamine-hydrolyzing]
    XP_001347408.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037281.1 Reference assembly

      Range
      482527..484194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001347372.1 → XP_001347408.1  GMP synthase [glutamine-hydrolyzing] [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001347408.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8IJR9, Q9U775
      UniProtKB/TrEMBL
      A0A024V650, A0A024VQX8, A0A024W6E9, A0A024WQ52, A0A024X752, A0A0L0CX40, A0A0L1IFH6, A0A0L7KGS6, A0A0L7M8F2, W4IG59, W4J3D0, W7FC96, W7FID6, W7JN10, W7K581
      Conserved Domains (1) summary
      PRK00074
      Location:7 → 555
      guaA; GMP synthase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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