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    Tle3 TLE family member 3, transcriptional corepressor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84424, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tle3provided by RGD
    Official Full Name
    TLE family member 3, transcriptional corepressorprovided by RGD
    Primary source
    RGD:620292
    See related
    EnsemblRapid:ENSRNOG00000013013 AllianceGenome:RGD:620292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Esp3
    Summary
    Predicted to enable transcription corepressor activity. Involved in regulation of DNA-templated transcription. Located in nucleus. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 84.5), Adrenal (RPKM 70.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tle3 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (70753182..70799080)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (61857791..61903505)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (66296509..66342186)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693113 Neighboring gene uncharacterized LOC134480065 Neighboring gene uncharacterized LOC102551666 Neighboring gene uncharacterized LOC102552398 Neighboring gene ribosomal protein lateral stalk subunit P1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. rTLE3, a newly identified transducin-like enhancer of split, is induced by depolarization in brain. Feldman JD, et al. J Neurochem, 2000 May. PMID 10800926
    2. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Villanueva CJ, et al. Cell Metab, 2013 Mar 5. PMID 23473036, Free PMC Article
    3. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. Wang JC, et al. J Biol Chem, 2000 Jun 16. PMID 10748198
    4. Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9. van Tienen LM, et al. Elife, 2017 Mar 15. PMID 28296634, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of beta-catenin-TCF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transducin-like enhancer protein 3
    Names
    rTLE3
    transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
    transducin-like enhancer of split 3 homolog of Drosophila
    transducin-like enhancer of split 3, E(spl) homolog
    transducin-like enhancer of split 3, homolog of Drosophila E(spl)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053400.2 → NP_445852.1  transducin-like enhancer protein 3

      See identical proteins and their annotated locations for NP_445852.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9JIT3
      UniProtKB/TrEMBL
      A0A8I5ZNN2, A6J560
      Related
      ENSRNOP00000018467.7, ENSRNOT00000018467.8
      Conserved Domains (4) summary
      cd00200
      Location:476 → 761
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:251 → 464
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:481 → 520
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      70753182..70799080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766347.4 → XP_008764569.1  transducin-like enhancer protein 3 isoform X1

      See identical proteins and their annotated locations for XP_008764569.1

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Related
      ENSRNOP00000079710.2, ENSRNOT00000108424.2
      Conserved Domains (4) summary
      cd00200
      Location:494 → 779
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:261 → 482
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:499 → 538
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    2. XM_006243214.5 → XP_006243276.1  transducin-like enhancer protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Conserved Domains (4) summary
      COG2319
      Location:483 → 775
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:489 → 774
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:494 → 533
      7WD40; WD40 repeat [structural motif]

    3. XM_006243213.5 → XP_006243275.1  transducin-like enhancer protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Related
      ENSRNOP00000109823.1, ENSRNOT00000164911.1
      Conserved Domains (4) summary
      COG2319
      Location:485 → 777
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:491 → 776
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:496 → 535
      7WD40; WD40 repeat [structural motif]

    4. XM_006243215.5 → XP_006243277.1  transducin-like enhancer protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Conserved Domains (4) summary
      COG2319
      Location:480 → 772
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:486 → 771
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:491 → 530
      7WD40; WD40 repeat [structural motif]

    5. XM_006243212.5 → XP_006243274.1  transducin-like enhancer protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Conserved Domains (4) summary
      COG2319
      Location:487 → 779
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:493 → 778
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 142
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:498 → 537
      7WD40; WD40 repeat [structural motif]

    6. XM_063266230.1 → XP_063122300.1  transducin-like enhancer protein 3 isoform X4

    7. XM_063266231.1 → XP_063122301.1  transducin-like enhancer protein 3 isoform X7

    8. XM_006243216.5 → XP_006243278.1  transducin-like enhancer protein 3 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Conserved Domains (4) summary
      cd00200
      Location:484 → 769
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:251 → 472
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:489 → 528
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    9. XM_006243219.5 → XP_006243281.1  transducin-like enhancer protein 3 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Conserved Domains (4) summary
      cd00200
      Location:479 → 764
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:251 → 467
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:484 → 523
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    10. XM_006243218.5 → XP_006243280.1  transducin-like enhancer protein 3 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Conserved Domains (4) summary
      cd00200
      Location:481 → 766
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:251 → 469
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:486 → 525
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    11. XM_006243217.5 → XP_006243279.1  transducin-like enhancer protein 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Conserved Domains (4) summary
      COG2319
      Location:477 → 769
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:483 → 768
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:488 → 527
      7WD40; WD40 repeat [structural motif]

    12. XM_006243220.5 → XP_006243282.1  transducin-like enhancer protein 3 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Conserved Domains (4) summary
      COG2319
      Location:472 → 764
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:478 → 763
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:483 → 522
      7WD40; WD40 repeat [structural motif]

    13. XM_006243221.5 → XP_006243283.1  transducin-like enhancer protein 3 isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Conserved Domains (4) summary
      cd00200
      Location:475 → 760
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:250 → 463
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:480 → 519
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    14. XM_063266234.1 → XP_063122304.1  transducin-like enhancer protein 3 isoform X12

    15. XM_006243211.5 → XP_006243273.1  transducin-like enhancer protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006243273.1

      UniProtKB/TrEMBL
      A0A8I5ZNN2
      Conserved Domains (4) summary
      cd00200
      Location:494 → 779
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:261 → 482
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:499 → 538
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    16. XM_063266232.1 → XP_063122302.1  transducin-like enhancer protein 3 isoform X10

    17. XM_063266233.1 → XP_063122303.1  transducin-like enhancer protein 3 isoform X11

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIT3.1 GenPept UniProtKB/Swiss-Prot:Q9JIT3

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