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    Gimap8 GTPase, IMAP family member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500112, updated on 5-Mar-2024

    Summary

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    Symbol
    Gimap8provided by RGD
    Full Name
    GTPase, IMAP family member 8provided by RGD
    Primary source
    RGD:1564570
    See related
    Ensembl:ENSRNOG00000020169 AllianceGenome:RGD:1564570
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IanT
    Summary
    Predicted to enable GTP binding activity. Predicted to act upstream of or within regulation of T cell apoptotic process. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and mitochondrion. Predicted to be active in cytosol. Orthologous to human GIMAP8 (GTPase, IMAP family member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 194.6), Lung (RPKM 143.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (78931003..78942491)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77600104..77611593)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78283356..78294838)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 775 Neighboring gene similar to Zinc finger and SCAN domain containing protein 2 (Zinc finger protein 29) Neighboring gene GTPase, IMAP family member 9 Neighboring gene GTPase, IMAP family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8. Webb LM, et al. PLoS One, 2014. PMID 25329815, Free PMC Article
    2. Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP/GDP-binding motifs. Dion C, et al. Int Immunol, 2005 Sep. PMID 16103028
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC116406

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of T cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of T cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase IMAP family member 8
    Names
    IAN-9
    immune-associated nucleotide-binding protein 9
    protein IanT

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033923.1 → NP_001029095.1  GTPase IMAP family member 8

      See identical proteins and their annotated locations for NP_001029095.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099228
      UniProtKB/Swiss-Prot
      Q3LF72, Q4KLG2
      Related
      ENSRNOP00000055946.4, ENSRNOT00000059173.4
      Conserved Domains (2) summary
      cd01852
      Location:49 → 247
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)
      cl38936
      Location:284 → 477
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      78931003..78942491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108126.2 → XP_038964054.1  GTPase IMAP family member 8 isoform X2

      Conserved Domains (2) summary
      cd01852
      Location:77 → 275
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)
      cl38936
      Location:312 → 475
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_006236441.5 → XP_006236503.1  GTPase IMAP family member 8 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHZ9
      Conserved Domains (2) summary
      cd01852
      Location:77 → 275
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)
      cl21455
      Location:312 → 505
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KLG2.1 GenPept UniProtKB/Swiss-Prot:Q4KLG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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