elnb elastin b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: elnbprovided by ZNC
Official Full Name: elastin bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061212-2
See related: Ensembl:ENSDARG00000069017 AllianceGenome:ZFIN:ZDB-GENE-061212-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eln2
Summary: Predicted to be an extracellular matrix structural constituent. Predicted to be located in collagen-containing extracellular matrix and extracellular region. Is expressed in bulbus arteriosus; cranium; swim bladder; and ventral aorta. Human ortholog(s) of this gene implicated in several diseases, including Williams-Beuren syndrome; aortic disease (multiple); autoimmune disease (multiple); cutis laxa (multiple); and retinal disease (multiple). Orthologous to human ELN (elastin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 21

Exon count:: 59

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (40839399..40880382, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (40816450..40857305, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

eln2 was highly expressed in the bulbus arteriosus, providing the unique architecture of elastin and the specific mechanical properties required by this organ.
Title: Differential expression of two tropoelastin genes in zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: elastin b

Names: tropoelastin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048064.2 → NP_001041529.2 elastin b precursor

Status: VALIDATED

Source sequence(s)

BX649570, CU302322

UniProtKB/TrEMBL

A0A8M1NAS7

Related

ENSDARP00000123914.1, ENSDART00000137696.4

Conserved Domains (1) summary

cl01807
Location:1278 → 1341

DUF1517; Protein of unknown function (DUF1517)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

40839399..40880382 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017352794.2 → XP_017208283.1 elastin b isoform X4

UniProtKB/TrEMBL

A0A8M6YV34
XM_021468862.1 → XP_021324537.1 elastin b isoform X8

UniProtKB/TrEMBL

A0A8M9P3C9

Conserved Domains (2) summary

pfam05642
Location:470 → 530

Sporozoite_P67; Sporozoite P67 surface antigen

cl01807
Location:986 → 1049

DUF1517; Protein of unknown function (DUF1517)
XM_017352796.2 → XP_017208285.1 elastin b isoform X7

UniProtKB/TrEMBL

A0A8M6YWX5
XM_021468861.1 → XP_021324536.1 elastin b isoform X6

UniProtKB/TrEMBL

A0A8M9PQI3

Conserved Domains (2) summary

pfam05642
Location:470 → 530

Sporozoite_P67; Sporozoite P67 surface antigen

cl01807
Location:1193 → 1256

DUF1517; Protein of unknown function (DUF1517)
XM_021468860.1 → XP_021324535.1 elastin b isoform X5

UniProtKB/TrEMBL

A0A8M9PTX8

Conserved Domains (2) summary

pfam05642
Location:470 → 530

Sporozoite_P67; Sporozoite P67 surface antigen

cl01807
Location:1278 → 1341

DUF1517; Protein of unknown function (DUF1517)
XM_017352791.2 → XP_017208280.1 elastin b isoform X2

UniProtKB/TrEMBL

A0A8M6YUG6
XM_017352793.2 → XP_017208282.1 elastin b isoform X3

UniProtKB/TrEMBL

A0A8M6Z2Z8
XM_017352790.2 → XP_017208279.1 elastin b isoform X1

UniProtKB/TrEMBL

A0A8M6Z3N0