dio3b iodothyronine deiodinase 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dio3bprovided by ZNC
Official Full Name: iodothyronine deiodinase 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-53
See related: Ensembl:ENSDARG00000095767 AllianceGenome:ZFIN:ZDB-GENE-070705-53
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dio3; si:ch211-156m19.1
Summary: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. Two paralogs of this gene have been identified in zebrafish on chromosomes 17 and 20. Both encode enzymatically active proteins; however, their gene structure and tissue expression patterns are markedly different. This gene is unique in that it has 2 exons compared to orthologs in all other vertebrate species studied to date, which are intronless. Knockdown of this gene causes severe microsomia, indicating that this gene is critical for the determination fetal size during early embryonic development. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2017]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (53803527..53810633)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (54014081..54014983)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of D1+D2 (D1D2MO) and knockdown of D3 (D3MO) both resulted in transcriptional regulation of energy metabolism and (muscle) development in abdomen and tail
Title: Deiodinase knockdown during early zebrafish development affects growth, development, energy metabolism, motility and phototransduction.
Dio3 expression controls zebrafish embryo size.
Title: Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size.
D3 is essential for normal zebrafish embryonic and early larval development
Title: Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish.
This study investigated deiodinase 1 (Dio1), deiodinase 2 (Dio2), and deiodinase 3 (Dio3) mRNA expression at the several zebrafish life stages and found life stage specific expression of these genes that were highly localized.
Title: Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables thyroxine 5'-deiodinase activity	IEA Inferred from Electronic Annotation more info
enables thyroxine 5-deiodinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hormone biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pharyngeal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neural retina development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swim bladder development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: iodothyronine deiodinase 3b

Names: D3; deiodinase 3; deiodinase, iodothyronine type IIIb; deiodinase, iodothyronine, type III; iodothyronine type IIIb; type III iodothyronine deiodinase

NP_001171406.2

EC 1.21.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177935.3 → NP_001171406.2 iodothyronine deiodinase 3b

See identical proteins and their annotated locations for NP_001171406.2

Status: REVIEWED

Source sequence(s)

KM281667

UniProtKB/TrEMBL

A0A3G0ZGD9

Related

ENSDART00000131982.3

Conserved Domains (1) summary

cl00388
Location:18 → 257

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold