4MKC: Crystal Structure of Anaplastic Lymphoma Kinase Complexed with LDK378

PDB ID: 4MKCDownload
MMDB ID: 119036
PDB Deposition Date: 2013/9/4
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.01  Å
Source Organism:
Similar Structures:
Biological Unit for 4MKC: monomeric; determined by author and by software (PISA)
Molecular Components in 4MKC
Label Count Molecule
Protein (1 molecule)
1
ALK Tyrosine Kinase Receptor
(Gene symbol: ALK)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
GLYCEROLGLYCEROL
2
1
5-chloro-N~2~-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine5-chloro-N~2~-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303