6I53: Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc

PDB ID: 6I53Download
MMDB ID: 170220
PDB Deposition Date: 2018/11/12
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.2  Å
Source Organism:
Lama glama▼
Similar Structures:
Biological Unit for 6I53: hexameric; determined by author and by software (PISA)
Molecular Components in 6I53
Label Count Molecule
Proteins (6 molecules)
2
Gamma-aminobutyric Acid Receptor Subunit Beta-3
Molecule annotation
2
Gamma-aminobutyric Acid Receptor Subunit Alpha-1
Molecule annotation
1
Gamma-aminobutyric Acid Receptor Subunit Gamma-2
Molecule annotation
1
Megabody38
Molecule annotation
Chemicals and Non-standard biopolymers (34 molecules)
1
14
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
4
beta-D-mannopyranosebeta-D-mannopyranose
3
11
alpha-D-mannopyranosealpha-D-mannopyranose
4
3
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
5
2
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303