6TO7: Crystal structure of the Orexin-1 receptor in complex with suvorexant at 2.29 A resolution

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PDB ID: 6TO7Download
MMDB ID: 182792
PDB Deposition Date: 2019/12/11
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.26  Å
Source Organism:
Similar Structures:
Biological Unit for 6TO7: monomeric; determined by author
Molecular Graphic ?
6TO7: Crystal structure of the Orexin-1 receptor in complex with suvorexant at 2.29 A resolution
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Data Set:
Molecular Components in 6TO7
Label Count Molecule
Protein (1 molecule)
1
Orexin Receptor Type 1
(Gene symbol: HCRTR1)
1 Protein
SS Diagram
Features
Domain Families
Specific Hits
Super Families
175150225300336336 residues, click to see VAST similar structures.helix 24-49helix 56-73helix 76-84helix 92-124helix 134-151helix 187-199helix 202-219helix 228-257helix 258-266helix 277-293helix 298-305helix 306-319strand 158-164strand 175-181putative peptide ligand binding pocketputative(41)location: 79, residue: Slocation: 82, residue: Vlocation: 83, residue: Dlocation: 95, residue: Clocation: 96, residue: Klocation: 97, residue: Vlocation: 98, residue: Ilocation: 99, residue: Plocation: 100, residue: Ylocation: 102, residue: Qlocation: 103, residue: Alocation: 106, residue: Vlocation: 149, residue: Llocation: 151, residue: Ilocation: 152, residue: Mlocation: 153, residue: Vlocation: 154, residue: Plocation: 155, residue: Qlocation: 188, residue: Plocation: 191, residue: Ylocation: 192, residue: Hlocation: 193, residue: Slocation: 195, residue: Flocation: 196, residue: Flocation: 197, residue: Ilocation: 199, residue: Tlocation: 200, residue: Ylocation: 255, residue: Ylocation: 258, residue: Ilocation: 259, residue: Slocation: 261, residue: Llocation: 262, residue: Nlocation: 265, residue: Klocation: 280, residue: Vlocation: 281, residue: Ylocation: 283, residue: Alocation: 284, residue: Flocation: 285, residue: Tlocation: 288, residue: Hlocation: 291, residue: Vlocation: 292, residue: Y7tmA_OXRcd15208 (23-313): orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors7tm_GPCRs superfamilycl28897(23-313): This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs),...
Chemicals and Non-standard biopolymers (31 molecules)
1
1
1
25
2
1
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