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6TO7:
Crystal structure of the Orexin-1 receptor in complex with suvorexant at 2.29 A resolution
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PDB ID:
6TO7
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MMDB ID:
182792
PDB Deposition Date:
2019/12/11
Updated in MMDB:
2024/10
Experimental Method:
x-ray diffraction
Resolution:
2.26 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Default Biological Unit
All Biological Units (2)
Asymmetric Unit
Biological Unit for 6TO7: monomeric; determined by author
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Format:
ASN.1 (Cn3D)
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Data Set:
alpha-Carbons
Single 3D structure
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Molecular Components in 6TO7
Label
Count
Molecule
Protein (1 molecule)
A
1
Orexin Receptor Type 1
(Gene symbol:
HCRTR1
)
1 Protein
SS Diagram
Features
Domain Families
Specific Hits
Super Families
1
75
150
225
300
336
336 residues, click to see VAST similar structures.
helix 24-49
helix 56-73
helix 76-84
helix 92-124
helix 134-151
helix 187-199
helix 202-219
helix 228-257
helix 258-266
helix 277-293
helix 298-305
helix 306-319
strand 158-164
strand 175-181
putative peptide ligand binding pocket
putative(41)
location: 79, residue: S
location: 82, residue: V
location: 83, residue: D
location: 95, residue: C
location: 96, residue: K
location: 97, residue: V
location: 98, residue: I
location: 99, residue: P
location: 100, residue: Y
location: 102, residue: Q
location: 103, residue: A
location: 106, residue: V
location: 149, residue: L
location: 151, residue: I
location: 152, residue: M
location: 153, residue: V
location: 154, residue: P
location: 155, residue: Q
location: 188, residue: P
location: 191, residue: Y
location: 192, residue: H
location: 193, residue: S
location: 195, residue: F
location: 196, residue: F
location: 197, residue: I
location: 199, residue: T
location: 200, residue: Y
location: 255, residue: Y
location: 258, residue: I
location: 259, residue: S
location: 261, residue: L
location: 262, residue: N
location: 265, residue: K
location: 280, residue: V
location: 281, residue: Y
location: 283, residue: A
location: 284, residue: F
location: 285, residue: T
location: 288, residue: H
location: 291, residue: V
location: 292, residue: Y
7tmA_OXR
cd15208 (23-313): orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
7tm_GPCRs superfamily
cl28897(23-313): This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs),...
click domain graphic to toggle highlight of corresponding residues in 3D viewer
Chemicals and Non-standard biopolymers (31 molecules)
1
1
[(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone
2
1
TETRAETHYLENE GLYCOL
3
1
CITRIC ACID
4
25
octyl 1-thio-beta-D-glucopyranoside
5
2
(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate
6
1
SODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303
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