5DFP: Crystal structure of PAK1 in complex with an inhibitor compound FRAX1036

PDB ID: 5DFPDownload
MMDB ID: 136027
PDB Deposition Date: 2015/8/27
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 5DFP: monomeric; determined by author and by software (PISA)
Molecular Components in 5DFP
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase PAK 1
(Gene symbol: PAK1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
2
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303